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P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus



Alterations in skin microcirculation have been associated with damage in various microvascular beds [1]. Endothelial dysfunction in microcirculation plays a central role in the pathophysiology of rheumatic diseases, contributing substantially to the increased cardiovascular risk of these patients. Laser speckle contrast analysis (LASCA) is a novel non-invasive technique that can be used to evaluate endothelial function of skin microcirculation [2]. Previous studies have shown impaired skin endothelial function in patients with systemic sclerosis. To our knowledge, no previous study has evaluated skin microcirculation in patients with SLE using LASCA [3,4].

Design and Methods

Fifty-two individuals (25 SLE patients and 27 matched controls) were studied. In all subjects, forearm skin blood flow was recorded under standardized conditions using a laser speckle contrast imager (PeriCam PSI NR System, Perimed). Post-occlusive reactive hyperemia (PORH) was assessed following a standardized protocol and data were analyzed with signal processing software (PIMSoft, Perimed). The amplitude of PORH responses was expressed as a percentage increase between peak and baseline perfusion (%).


There were no differences among the two groups in age, sex, body mass index and hypertension status. Post occlusion reperfusion in SLE patients, was significantly lower as compared to non-SLE controls (155.5 ± 53.1 vs 194.5 ± 40.5% respectively, p = 0.004).


Patients with SLE demonstrate impaired skin microvascular endothelial function, providing a link that could explain the increased cardiovascular risk that these patients bear.


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Correspondence to Nikolaos Koletsos.

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Koletsos, N., Gkaliagkousi, E., Lazaridis, A. et al. P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus. Artery Res 25 (Suppl 1), S125 (2019).

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