- ARTERY 18, Guimaraes Oral Presentation abstracts
- Oral Session II - Young Investigator Award
- Open access
- Published:
2.8 Relationships Between Adiposity and Left Ventricular Function in Adolescents: Mediation by Blood Pressure and other Cardiovascular Measures
Artery Research volume 24, pages 71–72 (2018)
Abstract
Introduction
Increased adiposity is associated with poorer left ventricular (LV) function but the mediating role of blood pressure (BP) and other cardiovascular measures is unknown. We investigated the roles of potential mediators in adolescents in a UK birth cohort, the Avon Longitudinal Study of Parents and Children.
Methods
Fat and lean mass were assessed by dual energy X-ray absorptiometry (DXA) in 2,068 individuals (age 17.7(SD 0.32) years; 45% male; weight 67(SD 13) kg). BP was measured and echocardiography performed. Tissue Doppler systolic (s’), early diastolic longitudinal function (e’) and transmitral E/A were used as measures of LV systolic and diastolic function respectively. Mediation was estimated using structural equation modelling; height, sex, socioeconomic position, lean mass and smoking were included as potential confounders in all models.
Results
Table 1 shows the total and direct (total – indirect (mediated)) effects (standardized β) for each potential mediator, alongside %mediation. No convincing associations were found between fat mass and s’ or e’.
Conclusions
MAP, HR and EDV, an indicator of preload, are important mediators of the effect of adiposity on diastolic function in adolescence, while TPR appears to account for none of the effect. Absence of mediation by PP, in combination with the mediation by TAC, suggests that stroke volume contributes some mediative effect. These findings emphasise the importance of adiposity and risk factor control in adolescence.
Author information
Authors and Affiliations
Rights and permissions
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
About this article
Cite this article
Taylor, H., Hughes, A.D., Fraser, A. et al. 2.8 Relationships Between Adiposity and Left Ventricular Function in Adolescents: Mediation by Blood Pressure and other Cardiovascular Measures. Artery Res 24, 71–72 (2018). https://doi.org/10.1016/j.artres.2018.10.031
Published:
Issue Date:
DOI: https://doi.org/10.1016/j.artres.2018.10.031