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P122: Calculating Reservoir Pressure with or Without Flow Information: Similarity and Algorithmic Sensitivity At Radial Artery
Artery Research volume 20, pages 78–79 (2017)
Abstract
Background
Reservoir pressure is typically estimated from the pressure waveform information only. Comparability with estimates made using pressure and flow depend on assumptions, e.g. a proportional relationship between excess pressure and flow [1]. In this study, we compared (i) results using flow and pressure versus pressure-only at the radial artery, and (ii) two different algorithms used in the literature for pressure- only analysis.
Methods
Reservoir pressure separations were performed on 95 hypertensive individuals where radial pressure and flow velocity waveform measurements were available [2]. Algorithm (F) used flow and pressure information [3]. Algorithms (P1) and (P2) refer to the two different pressure-only implementations as used in [4, 5], and [1, 6], respectively. Reservoir curves characterized by physiologically implausible parameters, i.e. a rate constant b < 0 or an asymptotic pressure P∞ < 0, were discarded, leaving 63 subjects with valid reservoir pressure data.
Results
Estimated reservoir parameters are shown in Table 1. Algorithm (F) showed statistically significant differences in most of the parameters compared to (P1) and (P2), although, except time constant τ and asymptotic pressure P∞, there was a strong correlation between methods. Significant differences were observed in reservoir pulse pressure and area estimates between (P1) and (P2) despite their, in general, high correlation.
Conclusions
The discrepancies between (F) and (P1), (P2) raise concerns about the validity of the implicit assumptions in pressure-only reservoir pressure separation at the radial artery. Differences in (P1) and (P2) indicate some sensitivity of derived parameters to the algorithm employed.
References
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J. E. Davies, P. Lacy, T. Tillin, D. Collier, J. K. Cruickshank, D. P. Francis, A. Malaweera, J. Mayet, A. Stanton, B. Williams, K. H. Parker, S. A. McG Thom, and A. D. Hughes, “Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial.,” Hypertension, vol. 64, no. 1, pp. 60–8, Jul. 2014.
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Ebner, M., Parker, K., Vercauteren, T. et al. P122: Calculating Reservoir Pressure with or Without Flow Information: Similarity and Algorithmic Sensitivity At Radial Artery. Artery Res 20, 78–79 (2017). https://doi.org/10.1016/j.artres.2017.10.104
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DOI: https://doi.org/10.1016/j.artres.2017.10.104