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P73: The assessment of Pulmonary Artery Stiffness in Copd Using Cardiac Mri The Q/A Method
Artery Research volume 20, page 73 (2017)
Abstract
Background
Pulmonary artery distensibility and pulsatility has been studied in patients with COPD using cardiac MRI (CMRI) (1). However, pulmonary artery pulse wave velocity (PA- PWV) using ‘QA’ method (2) in CMRI has not been studied in this population. We hypothesized that patients with COPD have a higher PA-PWV compared to healthy individuals.
Methods
This analysis includes 23 COPD and 12 healthy volunteers (current or ex-smokers free from respiratory disease). Cardiac MRI was used to measure PA-PWV using a 3.0T GE Signa HDx MRI scanner (GE Healthcare), phase-contrast cross-sectional images using steady-state free precession sequence were obtained approximately 2 cm above the pulmonary valve, under free-breathing conditions. Aortic PWV was measured using the Sphymocor device along with mean arterial pressure (MAP), heart rate, lung function (forced expiratory volume in 1sec (FEV1) and forced vital capacity (FVC) and their ratio), 6-minute-walk-distance (6MWD) oxygen saturations.
Results
Patients with COPD and the healthy individuals were similar in age, gender and BMI (p > 0.05). Patients with COPD had greater PA-PWV and heart rate as well as poorer lung function and oxygen saturations and 6MWD (all p < 0.05) (Table-1). PA-PWV did not relate to age, BMI, AoPWV, MAP, heart rate, lung function, oxygen saturations, but PAPWV was greater in males than females (p < 0.05).
Conclusions
Patients with COPD have stiffer pulmonary arteries compared to healthy individuals, as measured by PA-PWV using the Q/A method. Further analysis will investigate the association between pulmonary artery stiffness and cardiac function.
References
Liu et al. (2011) Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) — the MESA COPD study.JCMR, (13(Suppl 1): P73.)
Hsu-Hsia Peng, et al. (2006) Estimation of Pulse Wave Velocity in Main Pulmonary Artery With Phase Contrast MRI: Preliminary Investigation, JMRI 24:1303–1310
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This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.
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Gale, N., Saikia, S., Munnery, M. et al. P73: The assessment of Pulmonary Artery Stiffness in Copd Using Cardiac Mri The Q/A Method. Artery Res 20, 73 (2017). https://doi.org/10.1016/j.artres.2017.10.089
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DOI: https://doi.org/10.1016/j.artres.2017.10.089