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Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis

Artery Research volume 27, pages 101–106 (2021)Cite this article

Abstract

Background

Arteriosclerosis Obliterans (ASO) is an important cause for lower limb amputation. We aimed to compare the effects of interventional and conservative therapies on lower extremity ASO, and to analyze the risk factors for prognosis.

Methods

Ninety-eight eligible patients were randomly divided into experimental (n = 50) and control groups (n = 48). Conservative therapy was conducted for control group, and experimental group was given conservative and interventional therapies. Their baseline clinical data, hospital stay length, claudication distance, Rutherford stage, diseased arteries, Ankle-Brachial Index (ABI), clinical outcomes and adverse events were recorded. Then they were divided into poor (n = 31) and good prognosis groups (n = 67), and risk factors were explored by univariate and multivariate analyses.

Results

The hospital stay length of experimental group was significantly shorter than that of control group (p < 0.05). After treatment, Rutherford stage decreased, and vascular patency rate and total response rate rose in experimental group (p < 0.05). Claudication distance and ABI significantly increased in both groups compared with those before treatment, especially in experimental group (p < 0.05). The incidence rates of cardiovascular and cerebrovascular events, amputation and death were significantly lower in experimental group (p < 0.05). Age, conservative therapy, smoking, hypertension, diabetes mellitus, hyperlipidemia and fibrinogen were independent risk factors for poor prognosis (p < 0.05). Age of >70 years old and fibrinogen level of >4 g/L had greater effects on prognosis.

Conclusion

Interventional therapy works well for lower extremity ASO, with high safety, easy recovery and mild complications. Poor prognosis is caused by old age, conservative therapy, smoking, hypertension, diabetes mellitus, hyperlipidemia and increased fibrinogen.

References

  1. Xie R, Feng YY, Wen YT, Ren W. Expression of RCAN1 and CnA in tissues of in-stent restenosis after intervention of lower extremity arteriosclerosis obliterans and its significance. J Shanghai Jiaotong Univ (Med Sci) 2017;37:298–304.

    Google Scholar 

  2. Tegn N, Abdelnoor M, Aaberge L, Ranhoff AH, Endresen K, Gjertsen E, et al. Health-related quality of life in older patients with acute coronary syndrome randomised to an invasive or conservative strategy. The After Eighty randomised controlled trial. Age Ageing 2018;47:42–7.

    Google Scholar 

  3. Bisdas T, Borowski M, Torsello G, First-Line Treatments in Patients With Critical Limb Ischemia (CRITISCH) Collaborators. Current practice of first-line treatment strategies in patients with critical limb ischemia. J Vasc Surg 2015;62:965.e3–73.e3.

    Google Scholar 

  4. Guo J, Guo L, Dardik A, Tong Z, Xing Y, Cai Z, et al. Analysis of 17 years of surgical treatment for chronic limb ischemia in a Chinese National Clinical Center for Geriatric Disorders (2002 to 2018). Int J Cardiol 2020;318:39–42.

    Google Scholar 

  5. Cai Z, Guo L, Qi L, Cui S, Tong Z, Guo J, et al. Midterm outcome of directional atherectomy combined with drug-coated balloon angioplasty versus drug-coated balloon angioplasty alone for femoropopliteal arteriosclerosis obliterans. Ann Vasc Surg 2020;64:181–7.

    Google Scholar 

  6. Zhang MX, Zhang ZX. [Application value of interventional therapy in lower extremity arteriosclerosis obliterans]. China Modern Doctor 2019;57:5–7, 13.

    Google Scholar 

  7. Li RS, Xing ZJ, Zhao H, Hao GQ, Zheng X, Deng ZH. [Effect and experience analysis of interventional therapy for arteriosclerosis obliterans of lower extremities]. China Pract Med 2018;13:73–4.

    Google Scholar 

  8. Yao W, Wang L, Chen Q, Wang F, Feng N. Effects of valsartan on restenosis in patients with arteriosclerosis obliterans of the lower extremities undergoing interventional therapy: a prospective, randomized, single-blind trial. Med Sci Monit 2020;26:e919977.

  9. Higashi Y, Miyata T, Shigematsu H, Origasa H, Fujita M, Matsuo H, et al. Two-year follow-up of vascular events in peripheral arterial disease treated with antiplatelet agents: a prospective observational multicenter cohort study (SEASON). Sci Rep 2017;7:6095.

    Google Scholar 

  10. Song XT, Liu B, Liu CW, Ni L, Zeng R, Ye W, et al. [Prevalence of asymptomatic carotid artery stenosis in patients with arteriosclerosis obliterans of lower extremities and risk factor analysis]. Zhonghua Yi Xue Za Zhi 2016;96:126–8.

    Google Scholar 

  11. Chen WN, Guo SN, Wang JY, Jia LQ, Li DY, Tian Y. [Correlation between autophagy and polarization of macrophages in atherosclerosis plaque in arteriosclerosis obliterans amputees]. Yao Xue Xue Bao 2016;51:68–74 [Article in Chinese].

    Google Scholar 

  12. Zhou Y, Zhang NR, Zheng ZN, Yang Y, Lyu BF, Wang HL, et al. Regular transient limb ischemia prevents atherosclerosis progression in hypercholesterolemic rabbits. Chin Med J (Engl) 2019;132:1079–86.

    Google Scholar 

  13. Chiang IH, Chen SG, Tzeng YS. Treatment of thromboangiitis obliterans using smoking cessation and far-infrared therapy: a case study. Ostomy Wound Manage 2017;63:20–3.

    Google Scholar 

  14. Hemsinli D, Altun G, Kaplan ST, Yildirim F, Cebi G. Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit. Diving Hyperb Med 2018;48:31–5.

    Google Scholar 

  15. Taneja Y, Ram P, Dhaked SK, Sen TK. Squamous cell carcinoma penis in a case of urethral stricture due to lichen sclerosus balanitis xerotica obliterans: a case report and review of literature. J Clin Diagn Res 2017;11:PD17–PD18.

    Google Scholar 

  16. Argyropoulou OD, Protogerou AD, Sfikakis PP. Accelerated atheromatosis and arteriosclerosis in primary systemic vasculitides: current evidence and future perspectives. Curr Opin Rheumatol 2018;30:36–43.

    Google Scholar 

  17. Ertugrul AS, Bozoglan A, Taspınar M. The effect of nonsurgical periodontal treatment on serum and gingival crevicular fluid markers in patients with atherosclerosis. Niger J Clin Pract 2017;20:361–8.

    Google Scholar 

  18. Önder E, Uyar Ş. CHAID analysis to determine socioeconomic variables that explain students’ academic success. Univers J Educ Res 2017;5:608–19.

    Google Scholar 

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Authors and Affiliations

  1. Department of Interventional Medicine, Fujian Medical University Affiliated Mindong Hospital, 355000, Fu’an, Fujian Province, P. R. China

    Lingxiong Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Jinqiu Xue & Chengmei Ruan

  2. Department of Radiological Imaging, Fujian Medical University Affiliated Mindong Hospital, 355000, Fu’an, Fujian Province, P. R. China

    Lijiao Xie

Authors
  1. Lingxiong Chen
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  2. Xuming Zhang
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  3. Fuyan Jiang
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  4. Zhida Yin
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  5. Jinqiu Xue
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  6. Chengmei Ruan
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  7. Lijiao Xie
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Corresponding author

Correspondence to Xuming Zhang.

Additional information

Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The original data are available from the corresponding author [XZ], upon reasonable request.

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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Chen, L., Zhang, X., Jiang, F. et al. Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis. Artery Res 27, 101–106 (2021). https://doi.org/10.2991/artres.k.210204.001

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  • DOI: https://doi.org/10.2991/artres.k.210204.001

Keywords

Artery Research

ISSN: 1876-4401

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