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Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVIo) in Community Dwelling Individuals

Artery Research volume 27, pages 53–58 (2021)Cite this article

Abstract

Cardio Ankle Vascular Index (CAVI) and mathematically corrected formula derived from it (CAVI0) are indices for arterial stiffness and atherosclerosis. Role of different atherosclerotic risk factors on CAVI and CAVI0 is not clear in the community dwelling individuals. This study aims to evaluate the association of different Cardiovascular Disease (CVD) risk factors on CAVI and CAVI0. Participants from a prospective cohort study have been recruited for CAVI measurement. Known risk factors for atherosclerosis were assessed in the individuals. CAVI and CAVI0 is highly correlated (Pearson’s r = 0.95 and p < 0.001). Further correlation analysis of the study variables with CAVI shows that CAVI is significantly correlated with age, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP). CAVI0 is also significantly correlated with age, SBP and MBP. CAVI0 is not correlated with DBP (Pearson’s r = 0.05 and p = 0.46). Among laboratory tests, CAVI and CAVI0 are correlated with Blood Urea Nitrogen (BUN) (r = 0.20, p = 0.009 and r = 0.22, p = 0.004 respectively) and also with HBA1c (r = 0.21, p = 0.006 and r = 0.25, p = 0.001 respectively). Multivariate analysis showed that only age is independent determinant of CAVI and CAVI0. As SBP and DBP are not independently associated with CAVI and CAVI0, these indices could be considered reliable in differentiating people with high risks of CVD, as it is not dependent on other risk factors. As CAVI0 is not correlated with DBP, when evaluating the results of CAVI0, we should consider that this index maybe not be reflective of DBP in the patient.

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Authors and Affiliations

  1. Department of Geronological Health Care, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

    Li-Ju Lin

  2. Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

    Nan-Chen Hsieh

  3. College of Nursing, School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

    Shu-Fang Vivienne Wu

  4. Department of Electrical Engineering, National Taipei University of Technology, 10608, Taipei City, Taiwan

    Tan-Hsu Tan & Azadeh Alizargar

  5. Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Chyi-Huey Bai

  6. Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

    Javad Alizargar

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  1. Li-Ju Lin
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  2. Nan-Chen Hsieh
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  3. Shu-Fang Vivienne Wu
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  4. Tan-Hsu Tan
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Correspondence to Javad Alizargar.

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Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The data that support the findings of this study are available from the corresponding author [JA], upon reasonable request.

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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Lin, LJ., Hsieh, NC., Wu, SF.V. et al. Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVIo) in Community Dwelling Individuals. Artery Res 27, 53–58 (2021). https://doi.org/10.2991/artres.k.201124.002

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  • DOI: https://doi.org/10.2991/artres.k.201124.002

Keywords

Artery Research

ISSN: 1876-4401

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