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Effects of Weight Loss on Vascular Function in Obese Individuals with Poor Cardiovascular Health: Design and Research Protocol of an Interventional Clinical Trial

Artery Research volume 26, pages 154–160 (2020)Cite this article

Abstract

Introduction

Excessive adipose tissue is associated with adverse metabolic effects and is an important risk factor for chronic diseases. According to the American Heart Association, most cardiovascular events can be prevented by adhering to healthy practices, reflecting cardiovascular health as poor, intermediate, and good.

Objective

To evaluate the effect of weight loss on vascular function, metabolic profile and inflammatory markers of obese subjects with poor cardiovascular health.

Methods

Obese individuals, both sexes, aged 40–70 years, will be instructed to follow a hypocaloric diet (−800 Kcal/day) for 16 weeks. Before and after intervention, participants will undergo clinical, nutritional (anthropometry and dual energy X-ray absorptiometry), biochemical, vascular and sleep evaluation. Patients will be submitted to sympathetic tone assessment using a frequency meter Polar® RS800 (Polar Electro OY, Kempele, Finland), oscillometric pulse wave analysis by Mobil-O-Graph® (IEM, Stolberg, Germany), post-occlusive microvascular reactivity by laser speckle contrast imaging, carotid ultrasound and degree of obstructive sleep apnea through the home polysomnography device (WatchPAT 200®). Serum levels of leptin, adiponectin, interleukin-6, tumor necrosis factor-alpha and C-reactive protein will be determined. Participants will be stratified in two groups according to cardiovascular health (poor vs. intermediate/ideal). Cardiovascular health is said to be ideal by the presence of optimal health behaviors (non-smokers, adequate body mass index, physical activity level and healthy eating pattern) and health factors (blood pressure, total cholesterol and blood glucose). Ideal cardiovascular health is considered for those with five or more metrics within this qualification, intermediate for presence of three or four metrics and poor for two or less metrics.

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Authors and Affiliations

  1. Department of Clinical Medicine, State University of Rio de Janeiro, Ave.Vinte e Oito de Setembro, 77 room 329, 20551-030, Vila Isabel, Rio de Janeiro, RJ, Brazil

    Michelle Rabello Cunha, Samanta Souza Mattos, Wille Oigman & Mario Fritsch Neves

  2. Department of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro, Rua São Francisco Xavier, 524, Pavilhão João Lyra Filho, 12th floor, room 12026D, 20550-900, Maracanã, Rio de Janeiro, RJ, Brazil

    Marcia Regina Simas Torres Klein

Authors
  1. Michelle Rabello Cunha
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  2. Samanta Souza Mattos
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  3. Marcia Regina Simas Torres Klein
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  4. Wille Oigman
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  5. Mario Fritsch Neves
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Corresponding author

Correspondence to Mario Fritsch Neves.

Additional information

Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The data that support the findings of this study are available from the corresponding author, MFN, upon reasonable request.

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Cunha, M.R., Mattos, S.S., Klein, M.R.S.T. et al. Effects of Weight Loss on Vascular Function in Obese Individuals with Poor Cardiovascular Health: Design and Research Protocol of an Interventional Clinical Trial. Artery Res 26, 154–160 (2020). https://doi.org/10.2991/artres.k.200731.001

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  • DOI: https://doi.org/10.2991/artres.k.200731.001

Keywords

Artery Research

ISSN: 1876-4401

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