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Measurement of Instantaneous Wave-free Ratio through a Diagnostic Catheter: Comparison of the Results between 4Fr and 5Fr

Artery Research volume 26, pages 143–147 (2020)Cite this article

Abstract

Background

Clinical evidence of coronary pressure assessment through a diagnostic catheter is limited. The aim of this study was to assess the difference, safety, and rate of successful measurement of Instantaneous Wave-free Ratio (iFR) through 4Fr and 5Fr diagnostic catheters.

Methods

This single-centre prospective study included 32 lesions among 24 patients exhibiting intermediate coronary stenosis on coronary angiography. iFR measurements were performed through 4Fr and 5Fr diagnostic catheters for each lesion. The primary outcome was the reliability, as assessed by a Bland—Altman plot, for comparison of the mean differences [mean ± 2 Standard Deviations (SDs)], and the agreement on the Kappa coefficient, using a threshold iFR value of 0.89. The secondary outcome was the rate of successful iFR measurement. Safety was assessed by procedural complications and in-hospital Major Adverse Cardiac Events (MACE).

Results

The mean difference was −0.0003 ± 0.058, according to the Bland–Altman plot. One lesion was out of the range of 2 SDs. There was good agreement (Kappa coefficient = 0.85), and the correlation coefficient between the 4Fr and 5Fr catheters was 0.948 (p < 0.001). The success rate was not significantly different between the 4Fr and 5Fr catheters (90.6% vs. 96.9%, p = 0.09), although the 4Fr catheter had a lower success rate. No procedural complications or in-hospital MACE occurred.

Conclusion

Our findings suggest that iFR measurements could be safely performed, with similar reliability and success rate, through either the 4Fr or 5Fr diagnostic catheter.

Highlights

  • Instantaneous Wave-free Ratio (iFR) measurements through 4Fr and 5Fr diagnostic catheters.

  • Correlation and agreement of iFR between 4Fr and 5Fr.

  • To compare the successful measurement of iFR values.

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Authors and Affiliations

  1. Department of Cardiology, Saitama Eastern Cardiovascular Hospital, Saitama, Japan

    Shinichiro Masuda, Ryota Uemura, Yoshiyuki Saiki & Tatsuo Haraki

  2. Department of Cardiovascular Surgery, Saitama Eastern Cardiovascular Hospital, Saitama, Japan

    Takeshi Lee

  3. Department of Cardiology, Ageo Central General Hospital, Saitama, Japan

    Shinichiro Masuda

  4. Department of Cardiology, Haibara General Hospital, Shizuoka, Japan

    Ryota Uemura

  5. Department of Cardiology, Nippon Medical School Hospital, Tokyo, Japan

    Yoshiyuki Saiki

Authors
  1. Shinichiro Masuda
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  2. Ryota Uemura
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  3. Yoshiyuki Saiki
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  4. Tatsuo Haraki
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  5. Takeshi Lee
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Corresponding author

Correspondence to Shinichiro Masuda.

Additional information

Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.

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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Masuda, S., Uemura, R., Saiki, Y. et al. Measurement of Instantaneous Wave-free Ratio through a Diagnostic Catheter: Comparison of the Results between 4Fr and 5Fr. Artery Res 26, 143–147 (2020). https://doi.org/10.2991/artres.k.200620.001

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  • DOI: https://doi.org/10.2991/artres.k.200620.001

Keywords

Artery Research

ISSN: 1876-4401

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