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Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort

Artery Research volume 26, pages 34–41 (2020)Cite this article

Abstract

Objective

The changing living patterns in China are accompanied by an increase in prevalence of cardiovascular disease for which obesity is a significant factor. This study investigated the association between obesity phenotypes and risk of cardiovascular disease in a Chinese cohort.

Methods

A sample of 10,826 community-dwelling individuals aged 40–79 years (mean age 62.2 ± 12.0 years) were stratified by categories of body mass index (BMI) (normal weight: BMI < 24 kg/m2; overweight: BMI of 25–28 kg/m2; obese: BMI > 28 kg/m2) and metabolic status and divided into six phenotypes: (1) normal metabolic status and normal weight; (2) normal metabolic status and overweight; (3) normal metabolic status and obese; (4) normal weight and dysmetabolic status; (5) dysmetabolic status and overweight; (6) dysmetabolic status and obese. The Atherosclerotic Cardiovascular Disease (ASCVD) risk score was determined based on cardiovascular risk factors.

Results

Prevalence of overweight and obesity was 15.2% and 25.2% respectively. After adjusting for confounding factors, ASCVD score was significantly higher in men [Odds Ratio (OR): 9.796, 95% confidence interval (CI): 5.833–16.450; p < 0.001] and women [OR: 5.821, 95% CI: 4.253–7.968; p < 0.001] with obese and dysmetabolic status compared to normal. The odds of reporting ASCVD risk was significantly higher in men (OR: 3.432, 95% CI: 1.965–5.996; p < 0.001) and women (OR: 4.647, 95% CI: 3.327–6.491; p < 0.001) with obese and dysmetabolic status compared to those with obese and normal metabolic status. In addition, the odds of reporting ASCVD risk was significantly lower in men (OR: 0.317, 95% CI: 0.142–0.707; p = 0.005) and women (OR: 0.487, 95% CI: 0.320–0.739; p = 0.001) with the overweight–dysmetabolic status phenotype compared to those with an overweight–normal metabolic phenotype.

Conclusion

Obese dysmetabolic individuals had the highest ASCVD risk score in all phenotypes. When BMI category was overweight, BMI played a more important role than metabolic status, whereas when BMI category was obesity, risk was more affected by metabolic status.

Highlights

What is already known about this subject?

  • Obesity presents a major risk for cardiovascular disease.

  • Some studies provide evidence that obesity has better outcome compared to lean counterparts.

What does this study add?

  • This study provides information that obese dysmetabolic individuals show the highest Atherosclerotic Cardiovascular Disease (ASCVD) risk score in all phenotypes in the whole cohort.

  • This study also indicates that body mass index (BMI) plays a more important role for estimation of CV risk than metabolic status in overweight, whereas risk is more affected by metabolic status in obesity.

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Author notes

  1. These two authors contributed equally to this work.

Authors and Affiliations

  1. Department of Geriatric Medicine, Shanghai Jiatong School of Medicine, Ruijin Hospital North, Shanghai, China

    Yueliang Hu & Junli Zuo

  2. Department of General practice, Jiading District Jiangqiao Community Health Service Center, Shanghai, China

    Shuping Zheng

  3. Department of General practice, Daning Community Health Service Center, Shanghai, China

    Jiehui Zhao

  4. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

    Isabella Tan, Mark Butlin, Alberto Avolio & Junli Zuo

Authors
  1. Yueliang Hu
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  2. Shuping Zheng
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  3. Jiehui Zhao
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  4. Isabella Tan
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  5. Mark Butlin
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  6. Alberto Avolio
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  7. Junli Zuo
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Corresponding author

Correspondence to Junli Zuo.

Additional information

Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The data that support the findings of this study are available from the corresponding author, Junli Zuo, upon reasonable request.

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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Hu, Y., Zheng, S., Zhao, J. et al. Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort. Artery Res 26, 34–41 (2020). https://doi.org/10.2991/artres.k.200306.001

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Artery Research

ISSN: 1876-4401

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