- Conference Abstract
- Open access
- Published:
P78 Endothelial Dysfunction and Arterial Stiffness During Type 2 Diabetes
Artery Research volume 25, page S121 (2019)
Abstract
Objective
We aimed to study Endothelial dysfunction and Arterial Stiffness in Diabetes mellitus.
Methods
29 women with type 2 diabetes and 8 non-diabetic controls were included. Vascular function was studied with pOpmetre® (Axelife SAS-France) to assess the foot to toe Pulse Wave Velocity; and EndoPAT2000® (ITAMAR-Israel) to measure endothelial vasodilatation dependent by measurement of reactive hyperhemic index (RHI).
Results
Diabetics were 56 ± 6 years vs 47 ± 9 years. Mean diabetes duration was 9.07 ± 6.15 years. RHI was normal in all controls (1.94 ± 0.68) and abnormal in 51.72% of diabetics (1.83 ± 0.12). An abnormal ftPWV was found in 38% of diabetic subjects (11.6 ± 7.7 m/s) vs 12% of controls (7.7 ± 2.3 m/s, normal <10 m/s). There was a positive correlation between ftPWV and age (r = 0.25; p = 0.001); ftPWV and duration of diabetes (r = 0.12; p = 0.03). At the same time we found a negative correlation between RHI and fasting blood glucose (r = −0.46; p = 0.01), HbA1c (r = −0.37; p = 0.04), triglycerides (r = −0.49; p = 0.03) and total cholesterol (r = −0.37; p = 0.04). In a rapid and non-invasive way, we found endothelial dysfunction in 51.72% of diabetics and arterial stiffness in 38% of them.
Conclusion
During diabetes, endothelial dysfunction and arterial stiffness are therefore dependent on the glycemic balance, the duration of diabetes and lipid parameters. However, these two parameters appear independently and differently associated with diabetic disease.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
About this article
Cite this article
Toure, M., Hallab, M., Thiam, S. et al. P78 Endothelial Dysfunction and Arterial Stiffness During Type 2 Diabetes. Artery Res 25 (Suppl 1), S121 (2019). https://doi.org/10.2991/artres.k.191224.108
Published:
Issue Date:
DOI: https://doi.org/10.2991/artres.k.191224.108