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P3 Factor Influencing Endothelial Function in Type 2 Diabetes Mellitus with Newly Diagnosed Hypertension
Artery Research volume 25, page S45 (2019)
Abstract
Background
Increased risk for cardiovascular diseases is associated with diabetes, can be partially attributed to endothelial dysfunction. However, the cumulative factors leading to endothelial dysfunction in Type 2 DM are not clear. In the current study, a novel attempt was made to understand factors influencing endothelial function (EF) in humans using Angiotensin Converting Enzyme (ACE) inhibition as a tool to alter EF.
Methods
Brachial Flow-mediated-dilation (FMD) was measured using ultrasonography in 60 diabetics with newly-diagnosed hypertension. Serum E-selectin, Vascular-Cell-Adhesion-Molecule-1 (VCAM-1), hsCRP, IL-10, Renin, Ang 1–7, Ang II and ACE 2 were measured using ELISA. Amplitude of change, calculated as absolute difference in values obtained at baseline (V1) from those after 3 months (V3) (V3−V1), of biomarkers were correlated with change in FMD and E-selectin after 3 months of ACE inhibition.
Results
FMDV3-V1 showed significant negative correlation with hsCRPV3-V1, FSV3-V1, PPSV3-V1 and HbA1cV3-V1 [(r = −0.3, p = 0.02), (r = −0.31, p = 0.01), (r = −0.27, p = 0.03) (r = −0.3, p = 0.02), respectively] and significant positive correlation with Ang1–7V3-V1 (r = 0.39, p = 0.002). E-selectin correlated positively with FSV3-V1, PPSV3-V1 , HbA1cV3-V1, VCAM-1V3-V1 and ReninV3-V1 [(r = 0.35, p = 0.006), (r = 0.32, p = 0.01), (r = 0.45, p = 0.0005), (r = 0.66, p < 0.001), (r = 0.53, p < 0.0001) respectively].
Conclusion
A balance between the Renin/ Ang II and Ang 1–7/ACE2 axis plays a significant role in EF. Additionally, reduction in blood sugar levels and vascular inflammation also improves EF.
References
De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol 2000;130:963–74.
Bernardi S, Michelli A, Zuolo G, Candido R, Fabris B. Update on RAAS modulation for the treatment of diabetic cardiovascular disease. J Diabetes Res 2016;2016:8917578.
Srivastava P, Badhwar S, Chandran DS, Jaryal AK, Jyotsna VP, Deepak KK. Imbalance between Angiotensin II - Angiotensin (1–7) system is associated with vascular endothelial dysfunction and inflammation in type 2 diabetes with newly diagnosed hypertension. Diabetes Metab Syndr 2019;13:2061–8.
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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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Srivastava, P. P3 Factor Influencing Endothelial Function in Type 2 Diabetes Mellitus with Newly Diagnosed Hypertension. Artery Res 25 (Suppl 1), S45 (2019). https://doi.org/10.2991/artres.k.191224.038
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DOI: https://doi.org/10.2991/artres.k.191224.038