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3.7 Exercise Systolic Blood Pressure Response and Incident Depressive Symptoms — The Maastricht Study
Artery Research volume 25, page S28 (2019)
Abstract
Background
Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but the association between exercise SBP and incident depressive symptoms is unknown. Therefore, we investigated whether an exaggerated exercise SBP is associated with a higher risk of depressive symptoms over time.
Methods
Longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n = 2,121; 51.3% men; age 59.5 ± 8.5 years). Exercise SBP was measured at baseline with a submaximal exercise cycle test. We calculated a composite score of exercise SBP based on 4 standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise and SBP 4 minutes after exercise. Clinically relevant depressive symptoms were determined annually at follow-up and defined as a Patient Health Questionnaire score of > = 10.
Results
After a mean follow-up of 3.9 years, 175 participants (8.3%) had incident clinically relevant depressive symptoms. A1 standard deviation higher exercise SBP composite score was associated with a higher incidence of clinically relevant depressive symptoms (hazard ratio: 1.27 [95% confidence interval: 1.04–1.54]). Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP and cardiorespiratory fitness.
Conclusion
A higher exercise SBP response is associated with a higher incidence of clinically relevant depressive symptoms.
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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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Zhou, T.L., Kroon, A., Henry, R. et al. 3.7 Exercise Systolic Blood Pressure Response and Incident Depressive Symptoms — The Maastricht Study. Artery Res 25 (Suppl 1), S28 (2019). https://doi.org/10.2991/artres.k.191224.020
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DOI: https://doi.org/10.2991/artres.k.191224.020