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Serum 25-Hydroxyvitamin D Deficiency and Insufficiency are Associated with Ankle-Brachial Index but not Arterial Stiffness in an Elderly Community-dwelling Chinese Population

Artery Research volume 25, pages 113–119 (2019)Cite this article

Abstract

Vitamin D deficiency may increase arterial stiffness, a sub-clinical symptom of Target Organ Damage (TOD). This study aimed to investigate the associations between total serum vitamin D level and arterial stiffness assessed by brachial-ankle Pulse Wave Velocity (baPWV) and atherosclerosis assessed by Ankle-Brachial Index (ABI) in a Chinese community-dwelling elderly cohort. About 175 elderly participants (91 males and 84 females) were recruited. The levels of total serum 25-hydroxyvitamin D [25(OH)D], blood glucose, lipids and pressure were determined with clinical tests. We found 87.4% of elderly Chinese showed vitamin D deficiency (<20 ng/mL) and insufficiency (21–29 ng/mL). For these patients, the total 25(OH)D was positively correlated with right (r = 0.230, p = 0.004) and left ABI (r = 0.212, p = 0.008), whereas there was no correlation with right and left baPWV (r = −0.136 and −0.137, p = 0.092 and 0.089, respectively). In univariate linear regression, total serum 25(OH)D was positively associated with left and right ABI (p < 0.05). Multivariate regression suggested total serum 25(OH)D was independently correlated with the left and right ABI with adjustment for sex, age and Diastolic Blood Pressure (DBP). No significant association between total serum 25(OH)D level and baPWV was found. The study suggested that serum total 25(OH)D may be favorably associated with ABI in the elderly population with vitamin D deficiency and insufficiency; however, it may not correlated with arterial stiffness measured by baPWV. More prospective larger scale studies are warranted to validate these findings.

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Author notes

  1. These authors contributed equally to this study.

Authors and Affiliations

  1. Department of Geriatric Medicine, Ruijin Hospital North, Shanghai Jiao Tong School of Medicine, Shanghai, China

    Junli Zuo

  2. Department of Cardiology, Ruijin Hospital North, Shanghai Jiao Tong School of Medicine, Shanghai, China

    Kun Qian & Yan He

  3. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

    Isabella Tan, Mark Butlin & Alberto Avolio

  4. Clinical Research Center, Ruijin Hospital North, Shanghai Jiao Tong School of Medicine, Shanghai, China

    Peizhan Chen

Authors
  1. Junli Zuo
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  2. Kun Qian
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  4. Isabella Tan
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Correspondence to Junli Zuo or Peizhan Chen.

Additional information

Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The Numeric data used to support the findings of this study are restricted by the Ethics Committee of Ruijin Hospital North in order to protect PATIENT PRIVACY. Data are available from Junli Zuo (zuo-junli@163.com) for researchers who meet the criteria for access to confidential data.

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Zuo, J., Qian, K., He, Y. et al. Serum 25-Hydroxyvitamin D Deficiency and Insufficiency are Associated with Ankle-Brachial Index but not Arterial Stiffness in an Elderly Community-dwelling Chinese Population. Artery Res 25, 113–119 (2019). https://doi.org/10.2991/artres.k.191203.001

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Keywords

Artery Research

ISSN: 1876-4401

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