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Treatment of White Coat HYpertension in the Very Elderly Trial (HYVET 2) - Feasibility of a Randomized Controlled Trial (Study Protocol)

Artery Research volume 25, pages 19–25 (2019)Cite this article

Abstract

The results of HYpertension in the Very Elderly Trial (HYVET) were crucial in providing evidence of benefit of the treatment of hypertension in those 80 years or older. Following a subsequent sub study analysis of the HYVET data there is a suggestion that 50% of patients in the main study had White Coat Hypertension (WCH), defined as clinic BP readings >140/90 mmHg and ambulatory BP readings <135/85 mmHg. Currently, definitive evidence in support of treatment for such individuals is not available. HYVET 2 has been designed in order to assess the feasibility of conducting a randomized controlled trial which might determine whether the treatment of WCH in the very elderly is clinically beneficial. One hundred participants aged ≥75 years diagnosed with WCH will be recruited from General Practices (GPs) in UK. Randomization will be 1:1 to a treatment arm (indapamide and perindopril) and control arm (no treatment) and follow up will be for 52 weeks. HYVET 2 will report on feasibility outcomes including participant recruitment, adherence and withdrawal rates, willingness of GPs to recruit and randomize patients and the frequency of a composite of cardiovascular events. Simple descriptive statistics will be presented.

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Authors and Affiliations

  1. Department of Medicine, Brighton and Sussex Medical School, Brighton, UK

    Michael Okorie, Khalid Ali & Chakravarthi Rajkumar

  2. Brighton and Sussex University Hospitals NHS Trust, Brighton, UK

    Michael Okorie, Khalid Ali, Nicky Perry & Chakravarthi Rajkumar

  3. Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, UK

    Stephen Bremner

  4. Department of Ageing and Health, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

    Nigel Beckett

  5. Department of Clinical Gerontology, King’s College Hospital, London, UK

    Stephen Jackson

  6. Sussex Community NHS Foundation Trust, Brighton, UK

    Richard Quirk

  7. University of Sussex, Brighton, UK

    Colin McAlister

  8. Norwich Medical School, University of East Anglia, Norwich, UK

    John Potter

  9. Faculty of Medicine, Imperial College London, UK

    Christopher Bulpitt

Authors
  1. Michael Okorie
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  2. Khalid Ali
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  3. Stephen Bremner
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  4. Nigel Beckett
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  5. Stephen Jackson
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  6. Richard Quirk
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  7. Colin McAlister
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  8. Nicky Perry
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  9. John Potter
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  10. Christopher Bulpitt
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  11. Chakravarthi Rajkumar
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Corresponding author

Correspondence to Michael Okorie.

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Peer review under responsibility of the Association for Research into Arterial Structure and Physiology

Data availability statement: The data that support any aspects of this study protocol are available from the corresponding author, (MO), upon reasonable request.

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Okorie, M., Ali, K., Bremner, S. et al. Treatment of White Coat HYpertension in the Very Elderly Trial (HYVET 2) - Feasibility of a Randomized Controlled Trial (Study Protocol). Artery Res 25, 19–25 (2019). https://doi.org/10.2991/artres.k.191106.001

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  • DOI: https://doi.org/10.2991/artres.k.191106.001

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Artery Research

ISSN: 1876-4401

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