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Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL
Artery Research volume 24, pages 32–39 (2018)
Abstract
Background
Coronary heart diseases are inversely related to plasma high-density lipoprotein (HDL) level. Paraoxonase-1 (PON1) is mainly associated with HDL and plays a vital role in protection of low-density lipoprotein (LDL) and HDL. The aim of this study was to investigate the association between paraoxonase activity (PON1) with lipid profile, apoA-I, apoB and apoB/apoA-I ratio in subjects with different level of HDL cholesterol (HDL-C).
Methods
135 subjects, 20–60 years old, contributed to this study. The subjects were divided into three groups (45 in each group) with different levels of HDL-C (High, Normal and Low). For each group, the activity of PON1 was measured using paraoxon as a substrate. Moreover, the serum level of lipid profile, ApoA and apoB were measured. The statistical analysis was performed using SPSS software.
Results
PON-1 activity and apoA-I level were decreased in subjects with lower level of HDL-C (P < 0.001). ApoB and apoB/apoA-I ratio were higher in subjects with lower level of HDL-C (P < 0.001). Serum PON-1 activity was positively correlated with TC, TG, apo A-B, and LDL-C levels (P < 0.01).
Conclusions
In conclusion, determination of serum PON1 activity and lipoproteins may play important role in earlier prediction of CAD and help to design a therapeutic for treatment of CAD toward PON1 activity regulation.
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Teimouri, M., Nayeri, H. Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL. Artery Res 24, 32–39 (2018). https://doi.org/10.1016/j.artres.2018.10.227
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DOI: https://doi.org/10.1016/j.artres.2018.10.227