- ARTERY 18 Poster Session
- Poster Session II - Other
- Open access
- Published:
P162 Arterial Stiffness and Body Composition in Children and Adolescents
Artery Research volume 24, page 127 (2018)
Abstract
Objectives
Carotid-femoral pulse wave velocity (cfPWV) is a validated noninvasive measure of aortic stiffness. Risk factors for cfPWV are well described in adulthood, and furthermore cfPWV is associated with incident cardiovascular disease in adults (1). However, risk factors for arterial stiffness in childhood are poorly described (2). Accordingly, we sought to determine the risk factors for cfPWV in childhood and adolescence and hypothesized that cfPWV would be higher amongst those with greater adiposity.
Methods
We prospectively recruited 88 healthy children (mean age = 11.0 ± 5.3 years old). Age, weight, height, and blood pressure were measured. cfPWV was assessed using a semi-automated cuff-based device (Sphygmocor XCEL; AtCor Medical, Australia), and body composition using air displacement plethysmography (BOD POD; Cosmed, Italy) (3). Associations with cfPWV were determined by multivariable linear regression, with subsequent mediation analyses to inform likely causal pathways.
Results
After adjusting for age and sex, cfPWV was significantly associated with weight, body mass index (BMI), systolic blood pressure, mean blood pressure, heart rate, and lean body mass (LBM), while LBM was significantly associated with height, weight, BMI and fat mass (Table 1). After further adjusting for weight, mean blood pressure and heart rate, LBM remained significantly associated with cfPWV (ß = 0.68; p = 0.007). Mediation analyses indicate that weight mediates the association between age and cfPWV (PM = 76%), and that LBM mediates the relationship between weight and cfPWV (Figure 1).
Conclusion
Higher cfPWV in healthy children and adolescents is a function of growth, and this association may be in turn mediated by higher LBM rather than adiposity.
Author information
Authors and Affiliations
Rights and permissions
This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Cai, T., Meroni, A., Dissanayake, H. et al. P162 Arterial Stiffness and Body Composition in Children and Adolescents. Artery Res 24, 127 (2018). https://doi.org/10.1016/j.artres.2018.10.215
Published:
Issue Date:
DOI: https://doi.org/10.1016/j.artres.2018.10.215