P154 Does the Method of the Measurement of Blood Pressure Correlates Differently with Pulse Wave Velocity in Resistant Hypertension?

Abstract

Objective

Carotid-femoral Pulse Wave velocity (cfPWV), the gold standard for measuring stiffness, is a marker of organ damage (OLD). Even though cfPWV correlates with casual (BPc), central (CBP) and ambulatory (ABPM) blood pressure (BP), evidence is limited for resistant hypertension (RH).

Method

Thirty-three patients (age, 56.1 ± 8.2 years; weight, 78.0 ± 12.4 kg; height, 1.62 ± 0.08 m) with RH participated in a cross-sectional study. Outcomes included clinical data, BPc, ABPM, and carotid-femoral, cfPWV. Correlation analysis was conducted to assess the association between variables; independent t-tests were conducted to compare variables between those participants with cfPWV < and ≥ 10 m/s.

Results

Patients (20 women and 13 men) presented a peripheral systolic and diastolic BPc of 144.0 ± 3.8 mmHg and 82.0 ±1.9 mmHg, respectively. The cfPWV correlated with age (r = 0.356, p = 0.045), 24 h systolic BP (24 h SBP) nightime pulse pressure (night PP), 24 h pulse pressure (24hPP), casual systolic (SBPc) and diastolic BP (DBPc), central systolic (CSBP), diastolic (CDBP) and central pulse pressure (CPP); controlled for age the correlation remained significant for 24h SBP (r=0.446, p = 0.009) 24hPP (r = 0.464, p = 0.007), nightPP (r=0.365, p = 0.036), SBPc (r=0.620, p<0.001), DBPc (r=0.488, p = 0.004), PPc (r=0.592, p<0.001), central SBP (r = 0.587, p<0.001), central DBP (r=0.487, p = 0.001) and central PP (r = 0.506, p = 0.003). Patients with lower values of cfPWV (n = 26) showed lower SBPc (142.8 ± 15.9 vs. 162.6 ± 30.9 mmHg, p = 0.025), central SBP (136.0 ± 15.7 vs. 154.1 ± 31.8 mmHg, p = 0.041) and PP (49.6 ± 9.5 vs. 60.9 ± 20.8 mmHg, p = 0.043) than patients with cfPWV≥10 m/s (n = 7).

Conclusion

Our data shows that cfPWV correlates with SBPc, 24hSBP, 24hPP and CSBP, after controlled for age, in patients with RH.