P122 The Arterial Stiffness Dynamics Under the Effect of Rosuvastatin Added to Different Combinations of Antihypertensive Drugs

Abstract

We studied the influence of rosuvastatin adding to lisinopril/amlodipine or lisinopril/ hydrochlorothiazide fixed combinations on blood pressure (BP) and arterial stiffness dynamics in hypertensive patients of high or very high cardiovascular risk.

Methods

60 patients (36 men and 24 women aged 52.1 ± 7.3) with uncontrolled high or very high cardiovascular risk hypertension (HTN) were randomized into two groups. Group 1 (n = 30) received a fixed combination of lisinopril/amlodipine 10/5 mg/day. Group 2 consisted of 30 patients who received a fixed combination of lisinopril/hydrochlorothiazide 10–20/12.5 mg/day. The rosuvastatin 20mg/day was added in the both groups. The office BP, central (aortic) BP, augmentation index (AIx), carotid-femoral and carotid-radial pulse wave velocity (PWV) dynamics was evaluated during 24-week follow-up period.

Results

Baseline clinical characteristics did not differ in the groups. The office BP decreased in both groups from 173.3 ± 20.2/104.4 ± 14.0 to 131.2 ± 10.4/ 83.5 ± 7.8 mmHg (p < 0.001) in the 1-st group and from 168.6 ± 23.6/ 103.6 ± 15.6 to 135.6 ± 15.1/87.3 ± 11.5 mmHg (p < 0.001) in the 2nd one. The extent of office BP did not differ. However the degree of central systolic BP reduction was more prominent in the 2nd group (10.5 ± 6,8 and 6.5 ± 7.8 mmHg, respectively). The extent of AIx decline did not differ. Carotid-femoral PWV equally decreased in both groups (from 9.5 ± 1.7 to 8.8 ± 1.8; p = 0.043 and from 8.9 ± 1.2 to 8.1 ±1.4 m/s; p = 0.001, respectively). Carotid-radial PWV reliably declined only in the 1st group (from 9.5 ± 1.8 to 8.8 ±1.1 m/s; p = 0.034).

Conclusion

Addition of rosuvastatin to a fixed lisinopril/amlodipine combination has proved to be more effective than lisinopril/hydrochlorothiazide plus rosuvastatin combination in terms of impact on central aortic systolic BP and carotid-radial PWV.