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P104 Influence of Age and Gender on 24-Hour Variability of Central Blood Pressure: Findings from the International 24-Hour Ambulatory Aortic Blood Pressure Consortium (I24ABC)
Artery Research volume 24, page 109 (2018)
Abstract
Background
Conventional brachial cuff BP is known to vary according to age and gender, but the influence of these factors on 24-hour ambulatory central BP is unknown. We sought to determine this in a large healthy population from 11 centers in Europe and Asia.
Methods
24-hour ambulatory BP using a validated oscillometric device (Mobilo-graph, I.E.M, Stolberg, Germany) was performed in 1645 individuals free from anti-hypertensive drugs. Participants were categorized as young (Y: 13–39 years; M/F:219/112), middle-aged (MA: 40–66 years; M/F:545/553), and older (O: 67–104 years; M/F:86/130). Nighttime/daytime difference (N/D) was defined as nighttime (01.00–06.00) minus daytime (09.00–21.00) values / daytime values.
Results
Averaged 24-hour brachial BP was 125/79 (Y), 128/83 (MA), and 127/77 (O) mmHg. N/D for brachial SBP was -10.3% (Y), -6.4% (MA), and -4.7% (O), but was significantly less pronounced for central SBP: -1% (Y), -3.1% (MA), and -1.9% (O). Men, compared to women, had higher brachial and central SBPs, mainly in younger participants. Brachial pulse pressure (PP) displayed limited and age-dependent circadian variations, whereas central PP was substantially higher at nighttime: N/D was 24% (Y), 9% (MA), and 5.9% (O). Brachial and central PPs were higher in men in the younger group, but higher in women in middle-aged and older groups.
Conclusion
Both age and gender each have a significant influence on 24hour variability of central BP, but is different than variability in brachial BP. These data have potential implications for refining hypertension diagnosis and management.
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Weber, T., Protogerou, A., Wassertheurer, S. et al. P104 Influence of Age and Gender on 24-Hour Variability of Central Blood Pressure: Findings from the International 24-Hour Ambulatory Aortic Blood Pressure Consortium (I24ABC). Artery Res 24, 109 (2018). https://doi.org/10.1016/j.artres.2018.10.157
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DOI: https://doi.org/10.1016/j.artres.2018.10.157