P97 Family Patterns of Central Haemodynamics Across Three Generations in the Malmö Offspring Study

Abstract

Background

Markers of central haemodynamics have in recent years emerged as promising predictors of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and affect organs directly attached to large arteries. Carotid-Femoral pulse wave velocity (c-f PWV), Augmentation index (Aix), and central systolic blood pressure (cSBP) are variables from indirect measurements that reflect central haemodynamic and arterial stiffness. Family patterns exist [1].

Aim

To investigate if a relationship exists for patterns of central haemody-namics across three related generations, especially c-f PWV.

Methods

In all, 1131 participants from Malmoö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included in this study. c-f PWV was measured in grandparents and in all offspring. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were divided in quartiles by c-f PWV and offspring c-f PWV, and cSBP means were compared with one-way ANOVA analyses. Multiple regression analyses wereconductedtoadjust for age,sex, BMI,SBP and fasting glucose.

Results

c-f PWV in grandchildren was positively correlated with c-f PWV in parents (r = 0.26, p < 0.001) and in grandparents (r = 0.29, p < 0.001). Offspring c-f PWV correlated significantly with parental Aix and cSBP. Parents with high c-f PWV had offspring with statistically significant higher means of c-f PWV and cSBP than parents with low c-f PWV.

Conclusion

Measures of central haemodynamic are positively correlated across three generations in a population-based study.