P92 Parameters for Central Blood Pressure as Predictors for the Early Clinical and Functional Outcome after Stroke

Abstract

Background

High mortality and the rate of patients who depend on care after survived stroke illustrate the importance of prevention and the importance of the development of predictors to identify patients with a high risk for an adverse progress of disease. The level of the arterial blood pressure depends especially on the function of vessels. This function can be described by the pulse wave velocity (PWV). New studies show that there is a correlation between the central blood pressure and possible damages of end organs like heart, kidney and brain.

Methods

In a prospective study, we enrolled patients with acute ischemic stroke 7 ± 2 days after stroke onset. We conducted a 24-h-blood pressure measurement as well as a pulse wave analysis with the Mobil O Graph (I.E.M., Stolberg, Germany 2009). We objectified the functional outcome after stroke on basis of the National Institute of Health stroke scale (NIHSS).

Results

In univariate analysis, we show that patients with a good early outcome after stroke have a significant lower PWV (p = 0,027). Central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), central pulse pressure and augmentation index were tendentially but not significantly lower in patients with good early outcome.

Conclusion

In ischemic stroke low aortic stiffness is associated with good early outcome. Patients with good early outcome had tendentially but not significantly lower cSBP and cDBP.