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P25 24-Hour Aortic Ambulatory Blood Pressure is Better Associated with Common Carotid Artery Hypertrophy than 24-Hour Brachial Pressure — the Safar Study
Artery Research volume 24, page 87 (2018)
Abstract
Objective
Evidence suggests the superiority of office aortic pressure over brachial on the evaluation of vascular damage and prognosis of cardiovascular disease (CVD); 24-hour ambulatory blood pressure monitoring (ABPM) is regarded the optimal method for assessing blood pressure (BP) profile. The non-invasive 24-hour aortic ABPM is feasible and superior to 24-hour brachial regarding the association with left ventricular hypertrophy and diastolic dysfunction. The aim of our study was to examine the association of 24-hour aortic and brachial ABPM with common carotid artery (CCA) hypertrophy.
Methods
Consecutive subjects referred for CVD risk assessment underwent 24-hour aortic and brachial ABPM using a validated oscillometric brachial cuff-based devise (Mobil-O-Graph). CCA hypertrophy was assessed by high-resolution ultrasound (assessment of intima media thickness - IMT).
Results
497 subjects (aged 54 ± 13 years, 57% men, 80% hypertensives) were examined. Using Hotelling’s-Williams test it was shown that 24-hour aortic BP was significantly better correlated with IMT as compared with brachial BP (r: 0,254 vs. r: 0,202 for right IMT, r: 0,244 vs. r: 0,207 for left IMT, p < 0,05). Multivariate analysis (adjusted for possible confounders) revealed superiority of 24-hour aortic BP regarding the association with IMT as well as carotid hypertrophy. Last, in ROC analysis, aortic BP had a higher discriminatory ability compared to brachial for the detection of carotid hypertrophy (AUC: 0,707 vs. 0,656 for right carotid artery hypertrophy, AUC: 0,636 vs. 0,602 for left carotid artery hypertrophy, p < 0,05).
Conclusions
Non-invasively assessed 24-hour aortic pressure is more strongly associated with CCA IMT and provides a higher discriminatory ability for the detection of CCA hypertrophy.
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This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
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Argyris, A., Aissopou, E., Nasothymiou, E. et al. P25 24-Hour Aortic Ambulatory Blood Pressure is Better Associated with Common Carotid Artery Hypertrophy than 24-Hour Brachial Pressure — the Safar Study. Artery Res 24, 87 (2018). https://doi.org/10.1016/j.artres.2018.10.078
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DOI: https://doi.org/10.1016/j.artres.2018.10.078