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5.5 Mediator Effect of Cardiorespiratory Fitness on the Relationship Between Arterial Stiffness and Cognitive Function
Artery Research volume 24, page 79 (2018)
Abstract
Objective
The study aims to investigate the role of cardiorespiratory fitness as a mediator of the relationship between arterial stiffness and cognitive function in apparently healthy seniors.
Methods
This is a cross-sectional study comprising 155 participants (75.5 ± 6.5 years; 69.7% female). Arterial stiffness and cognitive function were assessed with carotid-femoral pulse wave velocity (cfPWV) (Sphygmo-Cor, AtCor Medical, Australia), and Montreal Cognitive Assessment (MoCA), respectively. Cardiorespiratory fitness was calculated using the 6-minute walk test. Simple mediation analysis with bootstrapped procedures was calculated with Hayes’s PROCESS macro for SPSS.
Results
After adjustments for gender and age, cardiorespiratory fitness significantly mediated the relationship between arterial stiffness and cognitive function (Indirect effect = −0.229 [95% CI, −0.455 to −0.046]).
Conclusion
The present findings suggest that cardiorespiratory fitness, independently of gender and age, is a mediator of the relationship between arterial stiffness and cognitive function.
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This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
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Nascimento, A., Silva, R., Carvalho, J. et al. 5.5 Mediator Effect of Cardiorespiratory Fitness on the Relationship Between Arterial Stiffness and Cognitive Function. Artery Res 24, 79 (2018). https://doi.org/10.1016/j.artres.2018.10.052
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DOI: https://doi.org/10.1016/j.artres.2018.10.052