- ARTERY 18, Guimaraes Oral Presentation abstracts
- Oral Session - Epidemiology + Special Populations
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1.1 Promotion of Arterial Stiffness by Childhood Cancer and its Characteristics in Adult Long-Term Survivors
Artery Research volume 24, page 67 (2018)
Abstract
Background
Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular (CV) sequelae in childhood cancer survivors (CCS). Therefore, we thought to evaluate the changes in arterial stiffness (AS) among long-term CCS compared to the general population.
Methods
AS was assessed by digital photoplethysmography (Stiffness Index (SI); m/s) among 1,002 participant of “Cardiac and Vascular late Sequelae in long-term Survivors of childhood cancer” study, diagnosed with neoplasia prior to an age of 15 years (1980–1990). A population-based subsample from the Gutenberg Health Study (GHS) (n = 5,252) was used for comparison. All subjects underwent a comprehensive, standardized clinical examination in the same study center.
Results
Compared to the population subsample with similar age range, CCS had higher SI in multivariable linear regression analysis with adjustment for cardiovascular risk factor and comorbidities (β = 0.66[0.51/0.80]; p < 0.0001). Moreover, SI was varying according to tumor entity with highest values in bone tumors. Interestingly, CCS demonstrated stiffer vessels than individuals from the population even in absence of a history of chemo- or radiotherapy (β = 0.56[0.16/0.96]; p = 0.0066) or prevalent hypertension (β = 0.66[0.50/0.81]; p < 0.0001) in fully-adjusted models. Finally, a 5.2-fold [3.9; 7.0] higher prevalence of SI values exceeding age-specific, population-based reference limits was observed among CCS compared to individuals from the population.
Conclusions
This is the first study demonstrating increased AS among long-term CCS. The data suggest that AS promotion might differ in individuals with childhood cancer: Cancer development and antineoplastic treatment might be relevant determinants.
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This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
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Arnold, N., Merzenich, H., Wingerter, A. et al. 1.1 Promotion of Arterial Stiffness by Childhood Cancer and its Characteristics in Adult Long-Term Survivors. Artery Res 24, 67 (2018). https://doi.org/10.1016/j.artres.2018.10.018
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DOI: https://doi.org/10.1016/j.artres.2018.10.018