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Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study

Artery Research volume 23, pages 14–19 (2018)Cite this article

Abstract

Background

Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. BMP-2 is a powerful inducer of bone formation and exposure to BMP-2 in the arteries leads to the loss of vascular smooth muscle cells (VSMC) markers and increase gene expression in favor of osteoblasts. BMP-7 is key factor in the bone and kidney and is suggested as inhibitor of vascular calcification. The main purpose of this clinical study was to find out the correlation between BMP-2 and BMP-7serum concentration and CAC in human for the first time.

Methods

In this study 84 patients with coronary artery disease who fulfilled inclusion and exclusion criteria, entered the study. For all patients a questionnaire consisting demographic data and traditional cardiovascular risk factors were completed. CT-Angiography was carried out to determine coronary artery calcium score and ELISA method was used for measuring BMP-2 and BMP-7serum concentrations.

Results

There was a significant positive correlation between BMP-2 serum concentration and total CAC score and also CAC of right coronary artery (RCA), left anterior descending (LAD), circumflex (CX), left main coronary artery (LMCA) (P < 0.05). Similar result was found for BMP-7 serum concentration except in LMCA (P > 0.05).

Conclusion

Based on our results, we can suggest BMP-2 and BMP-7 serum concentration as a probable biomarker for coronary artery disease. However, more studies with higher sample size are necessary for its confirmation.

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Authors and Affiliations

  1. Department of Cardiovascular Diseases, Razavi Hospital, Mashhad, Iran

    Saeed Nazemi & Sheyda Golmohammadzadeh

  2. Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran

    Atefeh Rezapour, Sepideh Elyasi, Azadeh Zaerzadeh & Amir Hooshang Mohammadpour

  3. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Mohammad Hasan Moallem

  4. Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran

    Mohammad Afshar

  5. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Afshar

  6. Birjand Cardiovascular Disease Research Center, Department of Cardiology, Birjand University of Medical Sciences, Birjand, Iran

    Elham Hashemi

  7. Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Vahid Jomezadeh

  8. Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amir Hooshang Mohammadpour

Authors
  1. Saeed Nazemi
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  2. Atefeh Rezapour
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  3. Seyed Mohammad Hasan Moallem
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  7. Sheyda Golmohammadzadeh
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  10. Amir Hooshang Mohammadpour
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Corresponding author

Correspondence to Amir Hooshang Mohammadpour.

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This is an open access article distributed under the CC BY-NC license. https://doi.org/creativecommons.org/licenses/by/4.0/

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Nazemi, S., Rezapour, A., Moallem, S.M.H. et al. Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study. Artery Res 23, 14–19 (2018). https://doi.org/10.1016/j.artres.2018.05.006

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  • DOI: https://doi.org/10.1016/j.artres.2018.05.006

Keywords

Artery Research

ISSN: 1876-4401

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