P110: Differences in Arterial Stiffness Measured by Cardio-Ankle Vascular Index in Patients with Normal and Decreased Renal Function

Abstract

Background

Arterial stiffness (AS) is a highly prognostic risk factor of cardiovascular diseases. The aim of this study was to investigate the relationships between cardio-ankle vascular index (CAVI) and eGFR in patients under the risk of cardiovascular disease.

Methods

This was a retrospective study of Lithuania High cardiovascular risk patients’ database. Demographic, renal function and AS data was gathered. Patients were divided into groups by gender and age by intervals of 5 years. Mean values of CAVI were further investigated according to the patients’ eGFR. ANOVA was used to compare mean values of CAVI.

Results

This study included data of 2070 patients aged from 40 to 65 years. The mean eGFR of the patients was 100.13 ml/min/1.73m², 58.7% were women. The increase in CAVI was observed with age in overall population, with mean values in different age groups of 6.55 ± 1.28, 7.13 ± 1.84, 7.71 ± 1.92, 7.79 ± 1.95, 7.73 ± 1.98, 8.06 ± 1.79, p < 0.001. Calculation of the mean CAVI in different age and gender groups of eGFR are presented in Table 1. Further comparison of mean values of CAVI did not yield statistically significant results.

Conclusions

Arterial stiffness increases with age in overall population. There was no statistically significant difference between mean values of CAVI in groups divided by age and gender according to eGFR.