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P91: Green Tea Extract Reduces Lipid Profile, Percentage of Aortic Augmentation Index and Increases Soluble Rage Concentrations in Normotensive Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blinded, and Placebo- Controlled Trial

Artery Research volume 20, pages 87–88 (2017)Cite this article

Abstract

Background

Type 2 diabetes mellitus is associated with premature atherosclerosis and arterial stiffening by an accumulation of advanced glycation end-products in vessel wall (1). Green tea polyphenols are considered a cardioprotective substance and may be used as an adjuvant for diabetes treatment, because its ability to stimulates the soluble RAGE secretion (2). There is no clinical evidence of the effect of green tea extract administration on metabolic parameters, arterial stiffness and the soluble RAGE expression.

Material and Methods

A double-blind, placebo-controlled, randomized clinical trial in normotensive patients with type 2 diabetes mellitus was conducted to identify the effect of green tea extract on arterial stiffness, metabolic and anthropometric parameters and on soluble RAGE (sRAGE) with the S100A1 ligand.

Results

We included 20 subjects, there was no difference between groups at baseline. There was a decrease in the green tea extract group on aortic augmentation index (21.12 ± 8.9 to 18.07 ± 9.7, p = 0.045), total cholesterol (203.9 ± 37.6 to 176.9 ± 25.9 mg/dl, p = 0.019) triglycerides (202.6 ± 146.9 to 123.2 ± 64.8 mg/dl, p = 0.023) and an increase in sRAGE (1358.5 ± 390.0 to 1281.1 ± 369.7 p = 0.052).

Conclusions

Green tea extract reduces lipid levels, percentage of aortic augmentation index and increases soluble RAGE concentrations in normoten-sive patients with Type 2 Diabetes.

References

  1. Schram MT, Henry RM, van Dijk RA, Kostense PJ, Dekker JM, Nijpels G, et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes. Hypertension. 2004;43(2):176–81.

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  2. Borges CM, Papadimitriou A, Duarte DA, De Faria JML, De Faria JBL. The use of green tea polyphenols for treating residual albuminuria in diabetic nephrop-athy: A double-blind randomised clinical trial. Scientific Reports. 2016;6

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Authors and Affiliations

  1. Physiology Department of the University of Guadalajara, University of Guadalajara, Mexico

    Fernando Grover Páez

  2. Experimental Therapeutic and Clinic Institute, University of Guadalajara, Mexico

    Fernando Grover Páez & David Cardona Müller

  3. National System of Researchers Grade 1, National Council of Science and Technology (CONACYT), Mexico

    Fernando Grover Páez

  4. Physiology Department of the University of Guadalajara, Experimental Therapeutic and Clinic Institute, Mexico

    Patricia Quezada Fernandez, Mariana Rodriguez de la Cerda, Jhonatan Trujillo Quiroz, Walter Trujillo Rangel & Marycruz Barocio Pantoja

  5. PNPC, National Council of Science and Technology (CONACYT), Mexico

    Patricia Quezada Fernandez, Jhonatan Trujillo Quiroz, Walter Trujillo Rangel & Marycruz Barocio Pantoja

  6. National System of Researchers, National Council of science and technology (CONACYT), Mexico

    David Cardona Müller

  7. National Council of Cardiology, Mexico

    David Cardona Müller

Authors
  1. Fernando Grover Páez
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  2. Patricia Quezada Fernandez
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  3. Mariana Rodriguez de la Cerda
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  4. David Cardona Müller
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  5. Jhonatan Trujillo Quiroz
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  6. Walter Trujillo Rangel
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  7. Marycruz Barocio Pantoja
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This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.

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Páez, F.G., Fernandez, P.Q., de la Cerda, M.R. et al. P91: Green Tea Extract Reduces Lipid Profile, Percentage of Aortic Augmentation Index and Increases Soluble Rage Concentrations in Normotensive Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blinded, and Placebo- Controlled Trial. Artery Res 20, 87–88 (2017). https://doi.org/10.1016/j.artres.2017.10.128

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  • DOI: https://doi.org/10.1016/j.artres.2017.10.128

Artery Research

ISSN: 1876-4401

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