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P171: Compliance of Extremely Dilated Main Pulmonary Arteries in Pulmonary Arterial Hypertension
Artery Research volume 20, pages 84–85 (2017)
Abstract
Background
Main pulmonary artery (MPA) dilation is a radiological sign of pulmonary hypertension (PH) and is an independent risk factor of sudden death (Żyłkowska et al, Chest 2012). Extreme MPA dilation is a rare consequence of PH. We hypothesize that the main pulmonary artery compliance is larger and contributes more to total arterial compliance in PH patients with an extremely dilated MPA when compared to patients with a less dilated MPA.
Methods
Cardiac magnetic imaging (CMR) scans of idiopathic and hereditary pulmonary arterial hypertension (PAH) patients were retrospectively analyzed. Six PAH patients with extremely dilated MPAs (≥45 mm diameter on transverse plain CMR images of the MPA) and six PAH patients with MPA diameter <45 mm were included. Total pulmonary arterial compliance (Ctot) was calculated by stroke volume (SV) over pulse pressure (PP) and MPA compliance (CMPA) by (Δarea*length)/PP (length was assumed 5 cm for all MPAs). CMPA/Ctot ratio could therefore be calculated by CMR derived flow images alone: CMPA/Ctot = (Δarea*length)/SV.
Results
Mean age in both groups was not different, mean pulmonary artery pressure was higher in patients with an extremely dilated MPA (73 ± 9.0 mmHg) compared to patients with non-extremely dilated MPA (48 ± 5.4 mmHg, p = 0.02). A trend toward a higher CMPA/Ctot ratio was observed in patients with extremely dilated MPA (p = 0.0534).
Conclusion
In PAH the contribution of the MPA to total compliance tends to be higher in patients with a MPA diameter ≥45 mm then in patients with a diameter <45mm.
References
Żyłkowska J, Kurzyna M, Florczyk M, Burakowska B, Grzegorczyk F, Burakowski J, Wieteska M, Oniszh K, Biederman A, Wawrzyńska L, Szturmo-wicz M, Fijałkowska A, Torbicki A. Pulmonary artery dilatation correlates with the risk of unexpected death in chronic arterial or thromboembolic pulmonary hypertension. Chest. 2012;142:1406–1416
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Groeneveldt, J., van der Wel, T., Marcus, T. et al. P171: Compliance of Extremely Dilated Main Pulmonary Arteries in Pulmonary Arterial Hypertension. Artery Res 20, 84–85 (2017). https://doi.org/10.1016/j.artres.2017.10.119
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DOI: https://doi.org/10.1016/j.artres.2017.10.119