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P168: Endothelial Regulation of Awv is Impaired During Increase in Blood Flow in Essential Hypertension
Artery Research volume 20, pages 83–84 (2017)
Abstract
Background
Arterial wall viscosity (AWV) depends on endothelium-derived factors in physiological conditions (1,2). Hypertension is characterized by an altered FMD during sustained flow increase due to endothelial dysfunction (3). Whether NO and EETs regulate change in AWV during increase in flow in hypertensive patients (HT) as compared with normotensive controls (NT) remains to be evaluated.
Methods
Radial artery diameter, wall thickness and arterial pressure were measured in 18 untreated essential HT and 14 frequency matched NT during hand skin heating with saline, L-NMMA, fluconazole, or both inhibitors infusion. AWV was estimated by the ratio of the area of the hysteresis loop of the pressure-diameter relationship (WV, viscous energy dissipated) to the area under the loading phase (WE, elastic energy stored).
Results
During saline infusion, WV, WE and WV/WE were not modified after heating in NT whereas WV/WE increased in HT (39.3 ± 12.0% to 49.9 ± 7.7%, p < 0.05) due to a larger increase in WV than WE (DWV: +41.5 ± 27.6% vs. ΔWE: +25.1 ± 28.4%, p < 0.05). With all inhibition sequences, WV/WE increased after heating in NT (p < 0.05) due to a larger increase in WV than WE (p < 0.05). In HT with fluconazole, L-NMMA and L-NMMA + fluconazole, WV/WE increased after heating (p < 0.05) due to a larger increase in WV than WE (p < 0.05), similarly to saline infusion. In all conditions, increase in shear stress was similar between NT and HT.
Conclusion
NO and EETs maintain stable AWV during change in flow in NT, and this regulation is lost in HT resulting in an increased AWV after heating.
References
Roca F, Bellien J, Iacob M, Remy-Jouet I, Joannides R. Evidence for a role of vascular endothelium in the control of arterial wall viscosity in humans. Submitted. 2017;
Boutouyrie P, Bézie Y, Lacolley P, Challande P, Chamiot-Clerc P, Benetos A, et al. In vivo/in vitro comparison of rat abdominal aorta wall viscosity. Influence of endothelial function. Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1346–55.
Bellien J, Iacob M, Remy-Jouet I, Lucas D, Monteil C, Gutierrez L, et al. Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension. Circulation. 2012 Mar 13;125(10):1266–75.
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Roca, F., Bellien, J., Iacob, M. et al. P168: Endothelial Regulation of Awv is Impaired During Increase in Blood Flow in Essential Hypertension. Artery Res 20, 83–84 (2017). https://doi.org/10.1016/j.artres.2017.10.117
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DOI: https://doi.org/10.1016/j.artres.2017.10.117