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Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value

Artery Research volume 17, pages 1–15 (2017)Cite this article

Abstract

Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.

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Authors and Affiliations

  1. Institute of Cardiovascular Science, University College London, W1T 7DN, London, UK

    Bryan Williams & Peter S. Lacy

  2. National Institute for Health Research, University College London Hospitals Biomedical Research Centre, W1T 7DN, London, UK

    Bryan Williams & Peter S. Lacy

  3. Novartis Pharma AG, CH-4002, Basel, Switzerland

    Patrick Brunel & Fabio Baschiera

  4. Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA

    Dion H. Zappe

  5. Jichi Medical School, 329-0498, Tochigi, Japan

    Kazuomi Kario

  6. Department of Cardiology, University of Cardiff, CF 14 4XN, Wales, UK

    John Cockcroft

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Williams, B., Brunel, P., Lacy, P.S. et al. Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value. Artery Res 17, 1–15 (2017). https://doi.org/10.1016/j.artres.2016.10.154

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Artery Research

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