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P4.05 An Examination of the Cardiac Mechanics and Pulse Pressure Waveforms That Underpin Ventricular-Arterial Interaction At Rest and During Exercise
Artery Research volume 6, page 184 (2012)
Abstract
Background
In healthy humans the left ventricle (LV) and the arterial system reciprocally interact to meet the circulatory demands of the body both at rest and during exercise. Ventricular-arterial interaction (VAI) can be quantified non-invasively using the ratio of arterial (Ea) and ventricular (Ees) elastances. However, Ees is a global measure of LV systolic function and Ea does not take into account the effect of wave reflections. Speckle tracking echocardiography (STE) and pulse wave analysis (PWA) allow for regional quantification of both cardiac and vascular functioning throughout the cardiac cycle. The purpose of this study was to characterise VAI using STE and PWA to explore the LV mechanics e.g. LV twist, and components of the pulse pressure waveform e.g. augmentation index (AIx), that underpin VAI at rest and during exercise.
Methods
9 (7 male) healthy participants (43±7 years) underwent simultaneous STE and PWA at rest and during exercise.
Results
During exercise there was a decrease in Ea/Ees due to significant changes in Ees but not Ea Whilst there were no significant changes in Ea during exercise both AIx and time to forward wave were significantly reduced. In contrast, the alteration in Ees was paralleled by significant changes in peak twist, time to peak twist, untwisting velocity and apical rotation.
Conclusions
The combined use of STE and PWA appears more sensitive to acute physiological changes induced by exercise than the classic VAI ratio: Ea/Ees. Future work will examine the sensitivity of combining STE and PWA to unmask subclinical cardiovascular pathology.
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This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.
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Kearney, M., Stone, K., Stohr, E. et al. P4.05 An Examination of the Cardiac Mechanics and Pulse Pressure Waveforms That Underpin Ventricular-Arterial Interaction At Rest and During Exercise. Artery Res 6, 184 (2012). https://doi.org/10.1016/j.artres.2012.09.153
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DOI: https://doi.org/10.1016/j.artres.2012.09.153