P1.23 Central Aortic Pressure and Arterial Stiffness Patterns According to Drugs and Gender in Hypertensive Patients

Abstract

Background

Previously we described differences in central pressures and arterial stiffening according to gender and age, which are related to increased risk in elder women (W) and different responses to treatment.

Objectives

To study different arterial stiffness patterns in essential hypertensives (H) according to gender and different antihypertensives.

Methods

We included 564 H from JAN2007 to DIC2010. Inclusion criteria: age >40 and <70,at least 2 CV risk factors and 6 mo.under stable monotherapy with atenolol (ATEN)n:114, amlodipine (AML)n:113, enalapril: (ENL) n:195 or losartan (LOS)n:142. A Control group (C) was also included (131p). All with a rate males/women (M/W) 2/1. Evaluations: BP, cIMT, Plaques, cf PWV, Endothelial Function (EF), Central/Peripheral Pulse Pressure (PPc/PPp) and Augmentation Indexes (Aix c /Aix p).(Hemodyn 4/Arterio-graph ®). Statistics: t test , ANOVA, Dunnet p <0,05.

Results

(only signif.) Peripheral BP, PP and PWV were higher in H than C. PPc and Aix c were higher in H than in C and in W than in M in every group. Aix p in H, were higher and positive in W and lower and negative in M . PWV was higher in M than W only in H. (table attached)

Conclusion

According to PP and Aix, two patterns: In M a“central stiffness pattern” with lower PPc than PPp, negative Aix p and higher PWV.

In W a “peripheral stiffness pattern” with higher PPc, positive Aix p and lower PWV. This last pattern could be related with the increased risk in elder W and was not corrected by treatment.