Skip to main content
Download PDF
  • Poster Presentation Abstracts: Epidemiology 4
  • Open access
  • Published:

P8.09 C-Reactive Protein is Associated with Endothelium-Dependent Alterations of Microcirculation in Patients with Metabolic Syndrome

Artery Research volume 3, pages 188–189 (2009)Cite this article

Abstract

Objective

Inflammation and early arterial damage are the possible mechanisms responsible for increased cardiovascular risk (CVR) in patients with metabolic syndrome (MetS). The aim of this study was to investigate the relationship between C-reactive protein (CRP) and arterial parameters of macro- and microcirculation in MetS patients.

Methods:

Subjects with MetS but without overt cardiovascular disease (n = 100; age 52.9 ± 6.4; 40% male) underwent detailed assessment of CVR factors. Measurements of local, regional and systemic arterial stiffness (AS) and endothelial function (EF) in brachial artery, finger and skin were performed.

Results:

Subjects were categorized according to CRP levels that relate to future CVR (<1, 1-3, and <3 mg/L). There was no significant difference in the mean age (51.2 ± 5.3, 53.6 ± 6.6 and 53.6 ± 7.2, p = 0.19) and gender distribution (p = 0.44) between the CRP categories. However, body mass index and waist circumference differed as did mean arterial pressure (p < 0.001, p = 0.001 and p = 0.016 respectively). Carotid AS (2.86 ± 1.09; 3.49 ± 1.52; 3.77 ± 1.68, p = 0.028) and several parameters of EF assessed by laser Doppler in microcirculation, e.g. percent change of skin perfusion (5090 ± 2385; 3636 ± 1777; 3885 ± 2731 %, p = 0.033) and time to half before hyperaemia (9.76 ± 15.10; 4.51 ± 8.04; 3.47 ± 5.69 s, p = 0.036), were significantly related to CRP category (Kruskal-Wallis Test). Multiple regression analysis revealed that CRP is independently associated only with alterations in microcirculation – percent change of skin perfusion (rest-to-peak flow, beta = 0.27, p = 0.016) but not other arterial parameters.

Conclusion:

In MetS patients CRP is independent predictor of endothelium-dependent alterations in skin microcirculation. Association between CRP categories and other parameters of microcirculation and carotid arterial stiffness was also observed.

Author information

Authors and Affiliations

  1. Vilnius University Hospital Santariskiu Klinikos, Center of Cardiology and Angiology, Vilnius University, Vilnius, Lithuania

    L. Ryliskyte, J. Badariene, V. Dzenkeviciute, A. Cypiene & A. Laucevicius

  2. Vilnius University, Faculty of Mathematics, Vilnius, Lithuania

    V. Skorniakov

Authors
  1. L. Ryliskyte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Badariene
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Dzenkeviciute
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Cypiene
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. Skorniakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Laucevicius
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

This is an open access article distributed under the CC BY-NC license. https://doi.org/creativecommons.org/licenses/by/4.0/

Reprints and permissions

About this article

Cite this article

Ryliskyte, L., Badariene, J., Dzenkeviciute, V. et al. P8.09 C-Reactive Protein is Associated with Endothelium-Dependent Alterations of Microcirculation in Patients with Metabolic Syndrome. Artery Res 3, 188–189 (2009). https://doi.org/10.1016/j.artres.2009.10.115

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2009.10.115

Artery Research

ISSN: 1876-4401

Contact us