P4.09 Effect of Vardenafil on Arterial Stiffness and Wave Reflection

Abstract

Introduction

While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the acute effect of vardenafil on arterial stiffness and wave reflections on patients with erectile dysfunction.

Methods:

Ten patients (mean age 58 ± 10 years) with erectile dysfunction received vardenafil 20 mg in a randomized, placebo-controlled, doubleblind, 2-way cross-over design. Aortic elastic properties were evaluated with carotid-femoral pulse wave velocity (cfPWV); wave reflection was evaluated with augmentation index (AIx) of the aortic pressure waveform. cfPWV and wave reflection indices were measured at baseline and for 3 hours after the vardenafil intake or placebo.

Results:

cfPWV decreased significantly (by 0.502 m/s, p <0.01), denoting a decrease in aortic stiffness. AIx decreased significantly (by 3.11%, p <0.01), denoting a decreased effect of wave reflection from the periphery. Aortic pulse pressure decreased significantly (by 5.09 mmHg, p <0.01). The effect of vardenafil lasted throughout the study (3 hours), being evident 30 to 60 minutes after drug intake.

Conclusion:

This study shows, for the first time, that vardenafil has a favorable effect on aortic stiffness and wave reflection in patients with erectile dysfunction.