P2.05 Central Hemodynamic Parameters and Arterial Stiffness in Paget’s Disease

Abstract

Background

Paget’s disease of bone (PDB) is a common disorder characterised by increased, disorganised bone turnover in affected areas with overgrowth of immature woven bone. An increased cardiovascular risk has been reported in some studies of PDB, possibly related to arterial wall calcifications. The aim of this study was to evaluate central hemodynamic parameters and arterial stiffness in PDB patients.

Methods:

11 PDB patients and 11 control subjects matched by age, weight, height and cardiovascular risk factors, were enrolled. Anthropometric measures, metabolic profile and information about PDB features (extension, therapy, and genetic alteration of disease) were made available for all subjects. Central hemodynamic parameters and carotid-femoral Pulse Wave Velocity (PWVcf) were assed non-invasively by Sphygmocor.

Results:

The PDB and the control group were comparable for age (PBD vs Control: 59 ± 8.0 vs 58 ± 7.2 yrs; M ± SD, height: 168 ± 6.7 vs 168 ± 6.0 cm and body weight: 78 ± 14 vs 77 ± 12 kg). PBD patients presented a significantly higher PWVcf (9.8 ± 1.8 vs 7.7 ± 1.5 m/s, p = 0.008) and a trend toward higher central PP (48 ± 19 vs 45 ± 10 mmHg, p = 0.60). The difference in PWVcf was confirmed after adjustment for age, gender, heart rate and central mean pressure (9.6 ± 0.54 vs 7.18 ± 0.53 m/s M ± SE; p = 0.006). Conclusions: PDB patients presented evidence of higher arterial stiffness as compared with control subjects. These results support the hypothesis that PDB is a systemic condition associated with increased cardiovascular risk.