P1.42 Preclinical Atherosclerotic Disease: Is it a Marker of Risk of Cardiovascular Events?

Abstract

Aim

We compared the severity of vascular disease (VD)by ultrasonography in patients (p.) with and without cardiovascular events (CVE), to detect high risk asymptomatic individuals.

Methods

We did in the same procedure 1) CIMT 2) Plaques characterization, 3) PWV and 4) FMD with a strict quality control. We set a score (VS) from 0 to 5 according to the severity of the VD. The CV Risk using Framingham score (FS) was also obtained from medical records.

Results

We performed a cross sectional, observational study on 581 p. (75 with CVE (AMI, Stroke, TIA, vascular thrombotic events) 62 + 10 y.o., 73 % males and 506 non CVE controls 52 + 14 y.o. p .001, 64% males p NS). FS was high (>20%) for 216p.(30,8%), moderate (10-20%) for 204p. (29%), and low (<10%) for 282p.(40,2%).

Table 1

Conclusions

1- The severity of the VD is higher in patients with CVE even when the cut off points of normality may need to be adjusted.2- The presence of a combination of vascular structural and functional disarrangements in asymptomatic subjects may suggest an increased risk of CVE. 3-A score of severity of VD