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P1.25 Arterial Properties in Relation to Genetic Variations in the Adducin Subunits in a White Population
Artery Research volume 2, page 98 (2008)
Abstract
Background
Adducin is a membrane skeleton protein, which consists either of α- and ß- or α- and γ-subunits. We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp), ADD2 (C1797T) and ADD3 (A386G).
Methods
We randomly recruited 1126 Flemish subjects (mean age, 43.8 years; 50.3% women). Using a wall-tracking ultrasound system, we measured the properties of the carotid, femoral and brachial arteries. We studied multivariate-adjusted phenotype-genotype associations, using a population-and family-based approach.
Results
In single-gene analyses, brachial diameter was 0.15 mm (P = 0.0022) larger, and brachial distensibility and cross-sectional compliance were 1.55 10−3/kPa (P = 0.013) and 0.017 mm2/kPa (P = 0.0029) lower in ADD3 GG than ADD3 AA homozygotes with an additive effect of the G allele. In multiple-gene analyses, the association of brachial diameter and distensibility with the ADD3 G allele only occurred in ADD1 GlyGly homozygotes. Otherwise, the associations between the arterial phenotypes in the 3 vascular beds and the ADD1 or ADD2 polymorphisms were not significant. In family-based analyses, the multivariate-adjusted heritability was 0.52, 0.38 and 0.30 for brachial diameter, distensibility, and cross-sectional compliance, respectively (P<0.001). There was no evidence for population stratification (0.07≤P≤0.96). Transmission of the mutated ADD3 G allele was associated with smaller brachial diameter in 342 informative offspring (–0.12±0.04 mm; P = 0.0085) and in 209 offspring, who were ADD1 GlyGly homozygotes (–0.14±0.06 mm; P = 0.018).
Conclusions
In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.
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This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.
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Seidlerova, J., Staessen, J.A., Bochud, M. et al. P1.25 Arterial Properties in Relation to Genetic Variations in the Adducin Subunits in a White Population. Artery Res 2, 98 (2008). https://doi.org/10.1016/j.artres.2008.08.332
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DOI: https://doi.org/10.1016/j.artres.2008.08.332