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Agreement between carotid and radial augmentation index: Does medication status affect the relation?

Artery Research volume 2, pages 74–76 (2008)Cite this article

Summary

Central augmentation index (AI) is an index for arterial stiffness and wave reflection, but the measurement requires technical precision. We recently reported that AI obtained directly from radial arterial pressure waveforms (without using the general transfer function) could provide equivalent information to carotid AI in healthy adults. The aim of the present study was to determine whether such association would exist among patients on anti-hypertensive drugs. Forty-six hypertensive patients taking blood pressure lowering medications (62 ± 9 years, mean ± SD) and 78 age-matched apparently healthy adults (60 ± 9 years) were studied. Carotid and radial AI were obtained using arterial applanation tonometry, and radial AI was calculated using the equation [(second peak radial systolic pressure - diastolic pressure)/(first peak radial systolic pressure - diastolic pressure) x 100]. Radial AI was strongly and positively correlated with carotid AI in medicated patients (r = 0.73, P < 0.0001) as well as in healthy controls (r = 0.84, P < 0.0001). The Brand—Altman plot demonstrated that the difference and SD between carotid and radial AI were not different between medicated patients and healthy controls (61.8 ± 7.7 vs 63.0 ± 7.7%). These results suggest that radial AI may be able to provide qualitatively similar information to carotid AI even in patients on antihypertensive medications.

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Authors and Affiliations

  1. Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin, 1 University Station, D3700, 78712-1204, Austin, TX, USA

    Jun Sugawara & Hirofumi Tanaka

  2. Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa & Takashi Yokoi

  3. Center for Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan

    Seiji Maeda

Authors
  1. Jun Sugawara
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  2. Hidehiko Komine
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  3. Koichiro Hayashi
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  4. Mutsuko Yoshizawa
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  5. Takashi Yokoi
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  6. Seiji Maeda
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  7. Hirofumi Tanaka
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Corresponding author

Correspondence to Jun Sugawara.

Additional information

Grant support: JSPS Postdoctoral Fellowships for Research Abroad (JS).

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This is an open access article distributed under the CC BY-NC license. https://doi.org/creativecommons.org/licenses/by/4.0/

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Sugawara, J., Komine, H., Hayashi, K. et al. Agreement between carotid and radial augmentation index: Does medication status affect the relation?. Artery Res 2, 74–76 (2008). https://doi.org/10.1016/j.artres.2008.03.001

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  • DOI: https://doi.org/10.1016/j.artres.2008.03.001

Keywords

Artery Research

ISSN: 1876-4401

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