P.050 Predictive Factors for Macro- and Micro-Vascular Complications in Type 2 Diabetes

Abstract

Patients with type 2 diabetes (DM2) have the extremely elevated cardiovascular risk. The aim of our cross-sectional study was to estimate the prevalence of macro- and micro-angiopathy in DM2 patients and to search out possible predictors of both angiopathies.

The sample of 415 DM2 outpatients -217(52%) men and 198 (48%) women, aged 66 ± 9y, average DM2 duration 9 ± 8y, was divided into 4 groups: MMC+, n = 112 (with manifest macroangiopathy), MMC-, n = 303 (without it), mmc+, n = 222 (with manifest microangiopathy) and mmc-, n = 193 (without it). All observed parameters were assessed by standard methods and evaluated by the Wilcoxońs test and the multiple logistic regression model.

Patients MMC+ suffered more often from nephropathy (66 vs 39 %, p<0,001), neuropathy (24 vs 14%, p<0,05) and retinopathy (18 vs 11%, p<0,05) than patients MMC-. Independent risk factors for MMC+ development were the age over 60 y. (RR 1,09, p<0,001), plasma glucose level>5,6 mmol/L (RR 1,70; p<0,05) and hs-CRP>1mg/L (RR 2,7; p<0,05). Protective factors for MMC+ was the female gender (RR 0,42; p<0,001), serum HDL-chol level>1 mmol/L (RR 0,15; p<0,05) and DBP>80 mmHg (RR 0,40; p<0,01). Duration of DM2>9 y. (RR 1,16; p<0,001), the age>60y. (RR 1,09; p<0,01) and hs-CRP>1mg/L(RR 2,99; p<0,01) were considered as independent predictive factors for mmc+.

Macro- and microvascular complications are associated closely in diabetic patients. Low casual DBP (below 80 mmHg) respectively high pulse pressure, high age (over 60 y.) and high hs-CRP (over 1mg/L) were considered as independent risk factors for the both angiopathies in DM2 patients.