P.088 Intensive Medical Therapy Normalises Flow-Mediated Vasodilatation and Intima-Media Thickness of Patients with Coexisting Heart Failure and Diabetes

Abstract

Coexistence of heart failure (HF) and type 2-diabetes is associated with high cardiovascular mortality. Intensive medical treatment of HF patients with diabetes may reduce the endothelial dysfunction and the accelerated atherosclerotic process seen in these patients.

To study this, we investigated the endothelial function and the presence of atherosclerosis measured by flow-mediated vasodilatation (FMD) and intima-media thickness (IMT) in intensively treated patients with coexisting HF and diabetes.

Methods

FMD of the brachial artery and IMT of the common carotid arteries were determined in 26 patients with HF and diabetes who were in intensive medical therapy as well as in 19 healthy controls. The two groups were matched according to age and sex. In all subjects left ventricular ejection fraction was measured by two-dimensional echocardiography (LVEF). Biochemical parameters including serum cholesterol, high and low density lipoprotein-cholesterol, triglyceride, glucose, hemoglobin/hemoglobin-A_1C (HbA_1C), brain natriuretic peptide (BNP) and N-terminal pro-BNP were also assessed.

Results

Mean FMD and IMT did not differ significantly between patients and controls. LVEF was lower in patients compared to controls (P < 0.001). The group of patients had a higher mean BNP, NT pro-BNP, triglyceride, HbA_1C and glucose in comparison to controls. Cholesterol, HDL-cholesterol and LDL-cholesterol were lower in patients compared to controls.

Conclusion

Intensively treated patients with coexisting HF and diabetes seem to have normal endothelial function as measured by FMD and they have no sign of accelerated atherosclerosis as measured by IMT. This suggests a positive effect of medication on the cardiovascular alterations in this group of patients.