- Poster Presentations
- Open access
- Published:
P.053 Prognostic Significance of Flow Mediated Dilatation of the Brachial Artery in Hypertensive Patients
Artery Research volume 1, page S40 (2006)
Abstract
Background
In uncomplicated hypertensive patients the prognostic role of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, has not been investigated.
Methods
A total of 175 prospectively identified uncomplicated hypertensives (age 53±5 years, 42% women, 48 with diabetes mellitus type 2) were studied. At baseline all subjects were untreated and underwent a baseline standard laboratory examinations. A standard echocardiogram was performed for the evaluation of LV anatomy and function and patients with systolic dysfunction or LV wall motion abnormalities were excluded. Endothelial function was measured as flow-mediated dilation of the brachial artery using high-resolution ultrasound.
Results
Patients were followed for 86±34 months (range 11–123 months). A first non fatal or fatal cardiovascular event occurred in 28 patients. The incidence of cardiovascular events was 1.4 and 3.1 per 100 patient-years in patients with a FMD above (n = 87) and below (n = 88) the median value, respectively (p < 0.005 by the log-rank test). In Cox analysis, controlling for age, gender, diabetes, hypercholesterolemia, smoking, and systolic BP at baseline, a low FMD conferred an increased risk of cardiovascular events (odds ratio 2.27, 95% confidence interval [CI] 1.01–5.15, p < 0.001).
Conclusions
The presence of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, identifies hypertensive patients at increased risk of non fatal and fatal cardiovascular events.
Author information
Authors and Affiliations
Rights and permissions
This is an open access article distributed under the CC BY-NC license https://doi.org/creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Salvetti, M., Muiesan, M.L., Paini, A. et al. P.053 Prognostic Significance of Flow Mediated Dilatation of the Brachial Artery in Hypertensive Patients. Artery Res 1 (Suppl 1), S40 (2006). https://doi.org/10.1016/S1872-9312(07)70076-5
Published:
Issue Date:
DOI: https://doi.org/10.1016/S1872-9312(07)70076-5