Skip to main content
  • Poster Presentations
  • Open access
  • Published:

P.024 Measuring Local Pulse Wave Velocity Using Non-Invasive Multiple M-Line Ultrasound



Local pulse wave velocity (PWV) provides direct information about the mechanical properties of an artery. Although PWV is related to arterial stiffness and both are predictors of cardiovascular events, no methods are currently available to measure local PWV non-invasively.


The common carotid artery (CCA) of 4 young subjects were measured with multiple M-line ultrasound, resulting in 14 distension waveforms spaced over 17 mm. PWV was determined by applying linear regression to the foot of the distension waveforms and the corresponding echo line position. The PWV was accepted for further analysis if the correlation coefficient of both parameters was above 0.95.


The local PWV measurement method had a good intra-subject coefficient of variation (CV) of <5%. The average PWV was 3.5±0.7 m/s with an inter-subject CV of 20%. One subject, with high blood pressure (140/90 mmHg), had a PWV of 4.6±0.2 m/s.


These results show a low PWV in the CCA compared to conventional carotid-femoral (CF) PWV. The muscular arteries that are part of the CF–trajectory increase the CF-PWV. Moreover since pulse waves travel in opposite direction, using the distance between carotid and femoral artery causes CF-PWV to overestimate true PWV.


Local PWV can be measured with good precision using multiple M-line ultrasound. The inter-subject variation (CV = 20%) exceeds the intra-subject variation (CV = 5%), enabling distinction between individual differences. More measurements are required to evaluate the accuracy of the local PWV method in vivo.

Author information

Authors and Affiliations


Rights and permissions

This is an open access article distributed under the CC BY-NC license

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hermeling, E., Reesink, K.D. & Hoeks, A.P.G. P.024 Measuring Local Pulse Wave Velocity Using Non-Invasive Multiple M-Line Ultrasound. Artery Res 1 (Suppl 1), S33 (2006).

Download citation

  • Published:

  • Issue Date:

  • DOI: