Fig. 3

The boundary conditions. The permeability function of the secondary valve and the flow rate of a valve with a diameter of 100 µm, as a function of transvalvular pressure gradient (A). An overview of the boundary conditions with the yellow hachures representing the fixed surfaces (B), a cross-section of the collecting vessel showing valve 1 and the fixed surrounding vessel wall (C), and the smoothened piecewise boundary load applied on each lymphangion’s vessel wall for the baseline model, with a maximum magnitude of 150 Pa (D)