Skip to main content
  • Poster Abstract Presentations
  • Open access
  • Published:

P9.12 The Relationship Between Retinal Vessel Calibre and Nocturnal Dipping Status: The SABPA Study

Abstract

Introduction

The relationship between a non-dipping blood pressure profile and retinal vessel calibre is not well established. A sustained increase in nocturnal arterial pressure may induce changes throughout the vascular tree, including the retinal microvasculature. We therefore explored the relationship between retinal vessel calibre and dipping status in a cohort of African and Caucasian teachers.

Methods

68 African and 81 Caucasian men were selected from those taking part in the follow-up phase of the SAPBA study. 24hr Ambulatory blood pressure measurements and dipping status were determined. The percentage mean arterial pressure (% MAP) dipping was calculated as: (diurnal MAP -nocturnal MAP)/diurnal MAP x 100. Retinal images were captured and the central retinal artery equivalent, central retinal vein equivalent (CRVE) and subsequent arteriolar-venular ratio (AVR) determined.

Results

African men demonstrated higher 24hr MAP and poorer % MAP dipping compared to Caucasian men. When sub-divided into non-dippers and dippers, African non-dippers demonstrated a reduced AVR and an increased CRVE (p<0.001) compared to their dipper counterparts. The AVR was positively (R2=0.34, β=0.38; p=0.001) while the CRVE was negatively (R2=0.24, β=−0.50; p<0.001) associated with % MAP during dipping. CRVE maintained a negative association with dipping status (non-dipper, yes/no) (R2=0.21, β=−0.38; p=0.001). These associations were independent of 24hr MAP. No associations were observed in the Caucasian men.

Conclusion

In this group of African men, a non-dipping blood pressure profile was associated with a reduced AVR and larger CRVE, reflecting microvascular deterioration as a result of prolonged periods of increased arterial pressure.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smith, W., Malan, N., Vilser, W. et al. P9.12 The Relationship Between Retinal Vessel Calibre and Nocturnal Dipping Status: The SABPA Study. Artery Res 8, 156–157 (2014). https://doi.org/10.1016/j.artres.2014.09.200

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.200