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P9.8 Arterial Stiffness and Paraoxonase Activity in Renal Transplant Recipients

Abstract

Increased lipid peroxidation and dyslipidemia are well known cardiovascular risk factors in renal transplanted (Tx) patients. Human serum paraoxonase (PON1) is the most potent high-density lipoprotein (HDL)-associated antioxidant enzyme. Previously decreased PON1 activity was shown in Tx recipients. Arterial stiffness parameters such as aortic augmentation index (AIx) and pulse wave velocity (PWV) are established markers of cardiovascular mortality in these patients. However, the association between PON activity and arterial stiffness has not been studied.

131 Tx patients and 63 age- and gender-matched healthy controls (C) were enrolled in the study. Lipid parameters and PON1 paraoxonase and arylesterase activities were measured. Arterial stiffness parameters (Aix, PWV, pulse pressure (PP), systolic and diastolic area indexes (SAI and DAI) and mean arterial pressure (MAP) were determined by arteriograph (Tensiomed).

Significantly lower paraoxonase and arylesterase activities were found in Tx patient compared to C subjects. Significantly higher MAP, PP, AIx and PWV, while significantly lower DAI and SAI were detected in Tx patients compared to C subjects. A significant negative correlation was found between arylesterase activity and PWV in Tx patients. Significantly higher total cholesterol (TC) and low-density cholesterol (LDL-C), while significantly lower HDL-C levels were found in Tx patients compared to C. Significant positive correlations were found between TC and PWV, and between LDL-C and PWV, while there were significant negative correlation between TC and DAI and between LDL-C and DAI in Tx patients.

Dyslipidemia and decreased antioxidant capacity characterized by PON1 activity may contribute to increased arterial stiffness in kidney transplant recipients.

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Szentimrei, R., Lőcsey, L., Seres, I. et al. P9.8 Arterial Stiffness and Paraoxonase Activity in Renal Transplant Recipients. Artery Res 8, 156 (2014). https://doi.org/10.1016/j.artres.2014.09.196

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.196