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P9.3 Lower Subendocardial Viability Ratio in Diabetic Women—Contributing to the Abrogated Cardioprotective Effect of Female Gender in Diabetes?

Abstract

The cardioprotective effect of female gender is abrogated in the presence of type 2 diabetes, and female diabetic patients thus face comparable cardiovascular risk as men with type 2 diabetes. The SubEndocardial Viability Ratio (SEVR) is an index of myocardial oxygen supply and demand that can be assessed non-invasively by applanation tonometry. We hypothesized that diabetic women would have lower SEVR than diabetic men and non-diabetic subjects independently of conventional risk markers and arterial stiffness.

Methods

86 patients (mean age 59±10 years, 41 women) with recently diagnosed (median 1.8 years) type 2 diabetes and 86 controls matched individually for gender and age were included. Radial artery pressure waveforms were obtained non-invasively by applanation tonometry. The central aortic waveform was derived using the SphygmoCor transfer function, which enabled calculation of SEVR. Arterial stiffness was assesses by the carotid-femoral pulse wave velocity (PWV).

Results

SEVR was significantly lower in diabetic women compared with i) diabetic men, (161%±26% vs 178%±32%, p<0.01), ii) non-diabetic women (185%±24%) and men (188±28%, p<0.001 for both comparisons). The differences remained significant in a multivariate analysis including age, mean blood pressure, heart rate, smoking, total cholesterol and PWV.

Conclusion

SEVR was significantly lower in diabetic women as compared with both diabetic men and non-diabetic subjects. This association was not mediated by arterial stiffness. Low SEVR may independently contribute to the increased cardiovascular morbidity seen in diabetic women.

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This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

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Laugesen, E., Høyem, P., Knudsen, S. et al. P9.3 Lower Subendocardial Viability Ratio in Diabetic Women—Contributing to the Abrogated Cardioprotective Effect of Female Gender in Diabetes?. Artery Res 8, 154–155 (2014). https://doi.org/10.1016/j.artres.2014.09.191

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.191