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P7.12 Circulating Vascular Growth Factors and Aortic Indices in Ghanaians with Diabetes and Hypertension

Abstract

Objectives

Impaired angiogenesis may be one mechanism linking large artery stiffness to organ damage. We investigated the relationship between arterial stiffness and regulators of angiogenesis as circulating vascular growth factors: vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1, Ang-2, which together with endogenous VEGF induces proliferation and the sprouting of new blood vessels, in Ghanaians with type 2 diabetes (T2DM) and hypertension (HTN).

Methods

63 T2DM plus HTN patients, 44 patients with T2DM only, 54 patients with HTN only and 39 subjects without T2DM nor HTN were included in the study. Aortic pulse wave velocity (PWVao) and aortic systolic pressure (SBPao), augmentation index (AIx) and aortic pulse pressure (PPao) were measured with Tensiomed’s Arteriograph. Fasting blood samples were measured for blood glucose, lipid profile, Ang-1, Ang-2 & VEGF.

Results

T2DM plus HTN patients had higher levels of Ang-1 (44.3 vs 36.1 and 36.3 ng/ml; p=0.004) & Ang-2 (875.65 vs. 764.4 and 710.35 pg/ml; p=0.009) than T2DM only and HTN only patients respectively. Ang-2 levels were positively associated with PWVao (r=0.17, p=0.03), SBPao (r=0.28, p<0.01), and AIx (r=0.22, p<0.01). When all the vascular growth factors were forced into multiple regression analysis, adjusting for age, BMI, systolic BP and fasting glucose, only Ang-2 emerged significantly related to PWVao (β=0.027, p=0.02), SBPao (β=0.54, p<0.01), AIx (β=0.3, p<0.01).

Conclusion

Vascular growth factors were related to arterial stiffness indices, Ang-2 independently, in Ghanaians, and higher in patients with both diabetes and hypertension than with either condition alone.

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This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

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Yeboah, K., Antwi, D., Gyan, B. et al. P7.12 Circulating Vascular Growth Factors and Aortic Indices in Ghanaians with Diabetes and Hypertension. Artery Res 8, 151 (2014). https://doi.org/10.1016/j.artres.2014.09.174

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.174