Skip to main content
  • Poster Abstract Presentations
  • Open access
  • Published:

P6.7 Sublingual Nitroglycerin in Patients with Heart Failure and Preserved Ejection Fraction: Impact on Central and Regional Carotid and Radial Input Impedance and Hemodynamics

Abstract

Background

The systolic blood pressure lowering effect of sublingual nitroglycerin (NTG) administration is thought to primarily arise from its action on wave reflection, although recent invasive data indicate that at least part of the blood pressure reduction can be ascribed to an effect on left ventricular dynamics.

Methods

Carotid and radial pressure waveforms and aortic, carotid and radial flow were measured in 19 HFpEF patients using applanation tonometry and pulsed Doppler ultrasound, respectively. Signals were time-aligned and global systemic as well as regional impedance and wave reflection analysis was applied.

Results

NTG lowered carotid systolic (130.8±26 at baseline vs. 110.4±18.4mmHg after NTG, P<0.01) and mean (92.5±18.4 vs.85.4±14.3) blood pressure. Global systemic effects included a decrease in systemic vascular resistance (1.00±0.32 vs. 0.88±0.28 mmHg.ml−1.s, P<0.05), characteristic impedance (0.133±0.089 vs. 0.089±0.034 mmHg.ml−1.s, P<0.05) and an increase in total arterial compliance (1.20±0.58 vs. 1.52±0.53 ml.mmHg−1, P<0.01). NTG had a major impact on the amplitude of the forward pressure wave (58±24.3 vs. 40.6±13.3 mmHg, P<0.01), with no significant change in reflection magnitude. Regional analysis demonstrated a large effect of NTG on carotid input impedance, lowering impedance over the entire frequency spectrum, with radial artery input impedance did not demonstrate any significant changes (despite large effects on pressure and flow waveform morphology).

Conclusions

Our data in patients with HFpEF confirm the absence of impact of NTG on reflection magnitude, and demonstrate large effects of NTG on the input impedance of the cerebral vascular district, with little effect on the distal forearm circulation.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Londoño, F., Segers, P., Shiva-Kumar, P. et al. P6.7 Sublingual Nitroglycerin in Patients with Heart Failure and Preserved Ejection Fraction: Impact on Central and Regional Carotid and Radial Input Impedance and Hemodynamics. Artery Res 8, 147 (2014). https://doi.org/10.1016/j.artres.2014.09.158

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.158