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P5.13 The Relationship Between Apolipoprotein B/ Apolipoprotein A1 Ratio, High Sensitivity C - Reactive Protein and Some Components of Metabolic Syndrome in Bulgarian Population

Abstract

The purpose of this study is to investigate the relations between apolipoprotein B (Apo B), apolipoprotein A1 (Apo A1), high sensitivity C- reactive protein (hsCRP) and the metabolic syndrome (MetS).

This study includes 500 clinically healthy people from Bulgaria - 201 (40,2%) men and 299 (59,8%) women. The following biomarkers are tested: apo B, apol A1, hsCRP, blood glucose, HDL-cholesterol, serum triglycerides (TG), LDL-cholesterol. One way ANOVA test, multiple comparison test of means and multiple logistic regression analyses are used.

The analysis shows that the odds of MetS for women increase by 1.08% for an increase of Apo B level with 1 mg/dl. When the level of hsCRP rises with 0.05 mg/l the odds of MetS for women increase with 1.9%. The odds of MetS for men increase by 4.75% for an increase of Apo B level with 1 mg/dl.

The odds of MetS for women increase by 1.77% for an increase of Apo B/Apo A1 ratio level with 0.01. When the hsCRP level rises with 0.05 mg/l the odds of MetS for women increase with 1.91%.

The hsCRP appears as the strongest indicator of MetS and it is more significant for women. The results for the first model indicate that the odds of MetS increase with rising of Apo B and hsCRP and decrease when Apo A1 increase. The results for the second model show that the odds of MetS increase with rising of Apo B/APO A ratio and hsCRP.

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Atanasova, G., Marinov, M. & Atanasov, M. P5.13 The Relationship Between Apolipoprotein B/ Apolipoprotein A1 Ratio, High Sensitivity C - Reactive Protein and Some Components of Metabolic Syndrome in Bulgarian Population. Artery Res 8, 145 (2014). https://doi.org/10.1016/j.artres.2014.09.150

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.150