Skip to main content
  • Poster Abstract Presentations
  • Open access
  • Published:

P4.13 Type 2 Diabetes is Associated with Altered Carotid Artery Mechanics Independently of Ageing and Mean Arterial Pressure—The Maastricht Study

Abstract

Introduction

Type 2 diabetes (T2D) is characterised by accelerated vascular ageing, which changes arterial wall structure and hence artery mechanics (e.g., pressure-area (P-A)). Pulse wave velocity (PWV) is Affected by both blood pressure and changes in wall mechanics. To better capture underlying changes in wall mechanics in T2D, we aimed to disentangle the vascular ageing phenomena (characterised by PWV) from pressure effects.

Methods

We studied young (<55y) and older (>70y) individuals without and with T2D matched at the group level for age, sex and MAP (n=29 each) from the Maastricht Study. Non-linear P-A curves were derived from carotid tonometry and echo-tracking, using Langewouters-model fits. Isobaric PWV (Bramwell-Hill) was determined at MAP.

Results

In individuals without T2D, the average P-A curve in older, as compared to younger individuals, was shifted rightward (diastolic area (Ad), mean±SD: 48.8±10.3 vs. 42.5±8.3mm2, p=0.003), which led to higher PWV (9.9±2.0 vs. 7.4±1.6m/s, p<0.001). Next, in younger individuals with T2D, as compared to those without, a similar pattern was found (Ad: 45.7±9.6vs. 42.5±8.3mm2, p=0.068 and PWV: 8.2±1.6 vs. 7.4±1.6m/s, p=0.072). Finally, in older individuals with T2D, as compared to those without, the P-A curve was again shifted rightward (Ad: 53.1±10.4 vs. 48.8±10.3mm2, p=0.034), but PWV was not significantly different (10.1±1.7 vs. 9.9±2.0m/s, p=0.29).

Conclusion

Independently of blood pressure, both ageing and T2D have a dilatory effect on carotid arteries, with ageing also clearly demonstrating stiffening. Although T2D is associated with additional stiffening in individuals younger than 55y, this was not observed in individuals older than 70y.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spronck, B., Hermeling, E., Henry, R. et al. P4.13 Type 2 Diabetes is Associated with Altered Carotid Artery Mechanics Independently of Ageing and Mean Arterial Pressure—The Maastricht Study. Artery Res 8, 142 (2014). https://doi.org/10.1016/j.artres.2014.09.136

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.136